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Dermatology: Advances on Pathophysiology and Therapies 2.0
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Dermatology: Advances on Pathophysiology and Therapies 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 3468

Special Issue Editors

Prof. Dr. Montserrat Fernández-Guarino

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Guest Editor
1. Servicio de Dermatología, Head of Hospitalization and Emergencies in Dermatology, Hospital Ramon y Cajal Madrid, Madrid, Spain
2. Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Madrid, Spain
Interests: cutaneous drug reactions; cutaneous lymphoma; dermatological emergencies; severe dermatological patient; erythroderma; cutaneous vasculitis; graft versus host disease; phototherapy; photobiology
Special Issues, Collections and Topics in MDPI journals
Dr. Belén De la Hoz

E-Mail Website
Guest Editor
Head, Allergy Department, University Ramón y Cajal Hospital, Carretera de Colmenar Km. 9, 100, 28034 Madrid, Spain
Interests: skin disease; dermatology
Dr. Javier Martínez-Botas

E-Mail Website
Guest Editor
Biochemistry-Research Department, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Carretera de Colmenar Km 9, 28034 Madrid, Spain
Interests: allergy; epitope mapping; microarray; lipid metabolism; cholesterol

Special Issue Information

Dear Colleagues,

Dermatology has undergone profound alterations over the last decade. Today, subspecialisation is needed for the management of inflammatory and complex dermatosis as remaining updated in all fields of dermatology is difficult. Furthermore, new target therapies are emerging along with the discovery of new paths and pathogenic mechanisms. Therefore, interaction with other medical specialties and multidisciplinary management is mandatory.

The new times in dermatology need to be open minded and innovative in hospital practise. Coordination between researchers, diagnosis and possible therapies undoubtedly will advance the work of physicians and benefit patients.

In this Special Issue, entitled “Dermatology: Advances on Pathophysiology and Therapies”, we aim to present this reality and a review of our experience working in coordination, adding a review of the relevant literature. We believe that would be a very useful reference and, thus, we invite physicians working in the field of this novel concept to share their experience and submit their work for publication in the International Journal of Molecular Science. We hope to develop an amazing Issue capable of representing the modern era in medical dermatology.

Prof. Dr. Montserrat Fernández-Guarino
Dr. Belén De la Hoz
Dr. Javier Martínez-Botas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunodermatology
  • cutaneous lymphoma
  • cutaneous drug reaction
  • erythroderma
  • psoriasis
  • atopic dermatitis
  • eczematous reactions
  • cutaneous manifestation of systemic diseases
  • cutaneous vasculitis

Related Special Issue

Published Papers (3 papers)

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Research

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11 pages, 2819 KiB  
Communication
Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians
by Luca Lo Piccolo, Wasinee Wongkummool, Phatcharida Jantaree, Teerada Daroontum, Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Warayuwadee Amornpinyo, Romanee Chaiwarith, Salin Kiratikanon, Rujira Rujiwetpongstorn, Napatra Tovanabutra, Siri Chiewchanvit, Chumpol Ngamphiw, Worrachet Intachai, Piranit Kantaputra and Mati Chuamanochan
Int. J. Mol. Sci. 2024, 25(12), 6466; https://doi.org/10.3390/ijms25126466 - 12 Jun 2024
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Abstract
Reactive pustular eruptions (RPEs) can manifest in a variety of conditions, including pustular psoriasis (PP) and adult-onset immunodeficiency syndrome due to anti-interferon-γ autoantibody (AOID). These RPEs can be attributed to different causes, one of which is genetic factors. However, the genetic basis for [...] Read more.
Reactive pustular eruptions (RPEs) can manifest in a variety of conditions, including pustular psoriasis (PP) and adult-onset immunodeficiency syndrome due to anti-interferon-γ autoantibody (AOID). These RPEs can be attributed to different causes, one of which is genetic factors. However, the genetic basis for pustular skin diseases remains poorly understood. In our study, we conducted whole-exome sequencing on a cohort of 17 AOID patients with pustular reactions (AOID-PR) and 24 PP patients. We found that 76% and 58% of the AOID-PR and PP patients, respectively, carried rare genetic variations within the filaggrin (FLG) gene family. A total of 12 out of 21 SNPs on FLG had previously received clinical classifications, with only p.Ser2706Ter classified as pathogenic. In contrast, none of the FLG3 SNPs identified in this study had prior clinical classifications. Overall, these variations had not been previously documented in cases of pustular disorders, and two of them were entirely novel discoveries. Immunohistochemical analysis of skin biopsies revealed that FLG variants like p.Ser860Trp, p.Gly3903Ter, p.Gly2440Glu, and p.Glu2133Asp caused reductions in FLG levels similar to the pathogenic FLG p.Ser2706Ter. These results highlight rare FLG variants as potential novel genetic risk factors contributing to pustule formation in both AOID and PP. Full article
(This article belongs to the Special Issue Dermatology: Advances on Pathophysiology and Therapies 2.0)
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Review

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16 pages, 1200 KiB  
Review
A Breakthrough in the Treatment of Necrobiosis Lipoidica? Update on Treatment, Etiopathogenesis, Diagnosis, and Clinical Presentation
by Maciej Naumowicz, Stefan Modzelewski, Angelika Macko, Bartosz Łuniewski, Anna Baran and Iwona Flisiak
Int. J. Mol. Sci. 2024, 25(6), 3482; https://doi.org/10.3390/ijms25063482 - 20 Mar 2024
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Abstract
Necrobiosis lipoidica (NL) is a rare granulomatous disease of a not fully understood etiopathogenesis. Classically, NL is associated with insulin-dependent diabetes mellitus. The disease often fails to respond to conventional treatments and adversely affects patients’ quality of life. First-line medications are usually topical [...] Read more.
Necrobiosis lipoidica (NL) is a rare granulomatous disease of a not fully understood etiopathogenesis. Classically, NL is associated with insulin-dependent diabetes mellitus. The disease often fails to respond to conventional treatments and adversely affects patients’ quality of life. First-line medications are usually topical corticosteroids, but patients respond to them with varying degrees of success. Other options include tacrolimus, phototherapy, cyclosporine, fumaric acid esters, and biologics (adalimumab, etanercept, and infliximab). Our review aims to present new therapeutic approaches potentially effective in patients with refractory lesions, describe the presumed etiopathogenesis, and provide diagnostic guidance for clinicians. The review concludes that Janus kinase inhibitors and biologics such as ustekinumab and secukinumab can be used effectively in patients with recalcitrant NL. Another promising treatment option is tapinarof (an aryl hydrocarbon receptor agonist). However, studies on larger groups of patients are still needed to evaluate the effectiveness of different therapeutic options and to define consistent treatment regimens for NL. It is advisable to improve the awareness of physicians of various specialties regarding necrobiosis lipoidica as lesions diagnosed earlier usually have a better response to treatment. Full article
(This article belongs to the Special Issue Dermatology: Advances on Pathophysiology and Therapies 2.0)
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21 pages, 3425 KiB  
Review
Clinical and Real-World Effectiveness of Mogamulizumab: A Narrative Review
by Montserrat Fernández-Guarino, Pablo Ortiz, Fernando Gallardo and Mar Llamas-Velasco
Int. J. Mol. Sci. 2024, 25(4), 2203; https://doi.org/10.3390/ijms25042203 - 12 Feb 2024
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Abstract
Mogamulizumab (MOG) is an antibody targeting the CCR4 receptor, authorized for relapsed or refractory peripheral T-cell (PTCL) and cutaneous T-cell lymphomas (CTCL). Its adoption in guidelines and endorsement by FDA and EMA established it as a systemic treatment, especially for advanced disease stages [...] Read more.
Mogamulizumab (MOG) is an antibody targeting the CCR4 receptor, authorized for relapsed or refractory peripheral T-cell (PTCL) and cutaneous T-cell lymphomas (CTCL). Its adoption in guidelines and endorsement by FDA and EMA established it as a systemic treatment, especially for advanced disease stages due to its comparatively lower toxicity. Clinical trials and real-world evidence have underscored its efficacy in advanced CTCLs, including mycosis fungoides and Sézary syndrome; PTCLs; and adult T-cell leukemia/lymphoma (ATLL), showcasing positive outcomes. Notably, the drug has demonstrated significant response rates, disease stability, and extended periods of progression-free survival, suggesting its applicability in cases with multiple treatment lines. Its safety profile is generally manageable, with adverse events (AEs) primarily related to the skin, infusion-related reactions, drug eruptions, autoimmune diseases, and skin disorders. The latter seem to appear as CCR4 can promote the skin-specific homing of lymphocytes, and MOG is directed against this receptor. While combination with immunostimulatory agents like interferon alpha and interleukin 12 has shown promising results, caution is urged when combining with PD1 inhibitors due to the heightened risk of immune-mediated AEs. The introduction of MOG as a systemic treatment implies a significant advancement in managing these diseases, supported by its favorable safety profile and complementary mechanisms. Full article
(This article belongs to the Special Issue Dermatology: Advances on Pathophysiology and Therapies 2.0)
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