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New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications
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New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 4211

Special Issue Editor

Dr. Evgenii Plotnikov

E-Mail Website
Guest Editor
1. Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia
2. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia
Interests: silver nanoparticles; antimicrobial conjugates; physical and chemical methods to increase activity; cytotoxicity

Special Issue Information

Dear Colleagues,

Antimicrobial properties are key parameters for the practical application of some nanoparticles. Infections and drug resistance remain key challenges in the 21st century and developing methods to fight them is an important task in modern science. Antimicrobial nanoparticles even have advantages over antibiotics, especially when applied topically. Antimicrobial nanoparticles can be used both in the creation of new pharmaceuticals and in the production of new materials, devices, tools, household items, and even clothing, due to their anti-infective properties against a wide range of microorganisms, including bacteria, protozoa, fungi, and viruses. The development of technologies for the creation, study, and effective use of antimicrobial nanoparticles, as well as the expansion of areas and methods for their use, significantly contribute to the fight against infection and drug resistance. This Special Issue, supervised by Dr. Evgenii Plotnikov (Tomsk Polytechnic University, Russia) and assisted by Dr. Anton Artamonov (Russian Academy of Sciences, Russia), aims to summarize and update achievements in this field, and author submissions will enable us to achieve this goal.

Dr. Evgenii Plotnikov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial nanoparticles
  • alternative to antibiotics
  • physical and chemical activation of nanoparticles
  • multi-drug resistance
  • mechanisms of anti-infective action

Published Papers (3 papers)

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Research

18 pages, 7692 KiB  
Article
Impact of Protein Nanoparticle Shape on the Immunogenicity of Antimicrobial Glycoconjugate Vaccines
by Marta Dolce, Daniela Proietti, Silvia Principato, Fabiola Giusti, Giusy Manuela Adamo, Sara Favaron, Elia Ferri, Immaculada Margarit, Maria Rosaria Romano, Maria Scarselli and Filippo Carboni
Int. J. Mol. Sci. 2024, 25(7), 3736; https://doi.org/10.3390/ijms25073736 - 27 Mar 2024
Viewed by 1127
Abstract
Protein self-assembling nanoparticles (NPs) can be used as carriers for antigen delivery to increase vaccine immunogenicity. NPs mimic the majority of invading pathogens, inducing a robust adaptive immune response and long-lasting protective immunity. In this context, we investigated the potential of NPs of [...] Read more.
Protein self-assembling nanoparticles (NPs) can be used as carriers for antigen delivery to increase vaccine immunogenicity. NPs mimic the majority of invading pathogens, inducing a robust adaptive immune response and long-lasting protective immunity. In this context, we investigated the potential of NPs of different sizes and shapes—ring-, rod-like, and spherical particles—as carriers for bacterial oligosaccharides by evaluating in murine models the role of these parameters on the immune response. Oligosaccharides from Neisseria meningitidis type W capsular polysaccharide were conjugated to ring-shape or nanotubes of engineered Pseudomonas aeruginosa Hemolysin-corregulated protein 1 (Hcp1cc) and to spherical Helicobacter pylori ferritin. Glycoconjugated NPs were characterized using advanced technologies such as High-Performance Liquid Chromatography (HPLC), Asymmetric Flow-Field Flow fractionation (AF4), and Transmission electron microscopy (TEM) to verify their correct assembly, dimensions, and glycosylation degrees. Our results showed that spherical ferritin was able to induce the highest immune response in mice against the saccharide antigen compared to the other glycoconjugate NPs, with increased bactericidal activity compared to benchmark MenW-CRM197. We conclude that shape is a key attribute over size to be considered for glycoconjugate vaccine development. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications)
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15 pages, 2720 KiB  
Article
Antibacterial and Photocatalytic Activity of ZnO/Au and ZnO/Ag Nanocomposites
by Mariana Busila, Viorica Musat, Petrica Alexandru, Cosmin Romanitan, Oana Brincoveanu, Vasilica Tucureanu, Iuliana Mihalache, Alina-Viorica Iancu and Violeta Dediu
Int. J. Mol. Sci. 2023, 24(23), 16939; https://doi.org/10.3390/ijms242316939 - 29 Nov 2023
Cited by 3 | Viewed by 1192
Abstract
The use of a combination of nanoparticles as antimicrobial agents can be one strategy to overcome the tendency of microbes to become resistant to antibiotic action. Also, the optimization of nano-photocatalysts to efficiently remove persistent pollutants from wastewater is a hot topic. In [...] Read more.
The use of a combination of nanoparticles as antimicrobial agents can be one strategy to overcome the tendency of microbes to become resistant to antibiotic action. Also, the optimization of nano-photocatalysts to efficiently remove persistent pollutants from wastewater is a hot topic. In this study, two composites ZnO/Au (1% wt.) and ZnO/Ag (1% wt.) were synthesized by simple aqueous solution methods. The structure and morphology of the r nanocomposites were analyzed by structural and optical characterization methods. The formation of AuNPs and AgNPs in these experiments was also discussed. The antimicrobial properties of ZnO, ZnO/Au, and ZnO/Ag nanomaterials were investigated against Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). The results showed an increase of 80% in the antimicrobial activity of ZnO/Au against Pseudomonas aeruginosa compared with 30% in the case of ZnO/Ag. Similarly, in the case of the S. aureus strain tests, ZnO/Au increased the antimicrobial activity by 55% and ZnO/Ag by 33%. The photocatalytic tests indicated an improvement in the photocatalytic degradation of methylene blue (MB) under UV irradiation using ZnO/Au and ZnO/Ag nanocomposites compared to bare ZnO. The photocatalytic degradation efficiency of ZnO after 60 min of UV irradiation was ∼83%, while the addition of AuNPs enhanced the degradation rate to ∼95% (ZP2), and AgNP presence enhanced the efficiency to ∼98%. The introduction of noble metallic nanoparticles into the ZnO matrix proved to be an effective strategy to increase their antimicrobial activity against P. aeruginosa and S. aureus, and their photocatalytic activity was evaluated through the degradation of MB dye. Comparing the enhancing effects of Au and Ag, it was found that ZnO/Au was a better antimicrobial agent while ZnO/Ag was a more effective photocatalyst under UV irradiation. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications)
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17 pages, 3924 KiB  
Article
Revealing the Second and the Third Causes of AgNPs Property to Restore the Bacterial Susceptibility to Antibiotics
by Nina Bogdanchikova, Maria Maklakova, Luis Jesús Villarreal-Gómez, Ekaterina Nefedova, Nikolay N. Shkil, Evgenii Plotnikov and Alexey Pestryakov
Int. J. Mol. Sci. 2023, 24(9), 7854; https://doi.org/10.3390/ijms24097854 - 26 Apr 2023
Cited by 2 | Viewed by 1357
Abstract
The increase in bacterial resistance to antibiotics is a global problem for public health. In our previous works, it was shown that the application of AgNPs in cow mastitis treatment increased S. aureus and S. dysgalactiae susceptibility to 31 antibiotics due to [...] Read more.
The increase in bacterial resistance to antibiotics is a global problem for public health. In our previous works, it was shown that the application of AgNPs in cow mastitis treatment increased S. aureus and S. dysgalactiae susceptibility to 31 antibiotics due to a decrease in the bacterial efflux effect. The aim of the present work was to shed light on whether the change in adhesive and anti-lysozyme activities caused by AgNPs also contribute to the restoration of bacterial susceptibility to antibiotics. In vivo sampling was performed before and after cow mastitis treatments with antibiotics or AgNPs. The isolates were identified, and the adhesive and anti-lysozyme activities were assessed. These data were compared with the results obtained for in vitro pre-treatment of reference bacteria with AgNPs or antibiotics. The present study revealed that bacterial treatments in vitro and in vivo with AgNPs: (1) decrease the bacterial ability to adhere to cells to start an infection and (2) decrease bacterial anti-lysozyme activity, thereby enhancing the activity of lysozyme, a natural “antibiotic” present in living organisms. The obtained data contribute to the perspective of the future application of AgNPs for recovering the activity of antibiotics rapidly disappearing from the market. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications)
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