Heart Failure: From Molecular Basis to Therapeutic Strategies

Dear Colleagues,

The molecular complexity of heart failure has dramatically increased since introducing the latest classification of preserved and reduced ejection fractions (HFpEF and HFrEF). Indeed, these two entities present different physiopathological mechanisms that are far from being elucidated. Understanding heart failure’s molecular mechanisms and providing deep phenotyping are crucial for developing novel and effective therapeutic strategies. In particular, HFpEF appears to be strictly related to cardiac metabolic remodeling and altered substrate utilization, leading to deficient energy production. This Special Issue aims to explore the molecular mechanisms involved in the pathogenesis of heart failure, evaluating the roles of various cellular and molecular players, including cardiomyocytes, fibroblasts, inflammatory mediators, and signaling cascades. Moreover, emerging therapeutic strategies, spanning from traditional pharmacological interventions to innovative gene- and cell-based therapies, will be considered.

Dr. Michele Ciccarelli
Guest Editor

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• heart failure
• cardiac metabolism
• mitochondria
• inflammatory pathway
• neurohormonal system
• therapeutical strategies