Molecular and Genetic Studies on Tourette Syndrome and Comorbid Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 354
Special Issue Editors
Interests: genetics; next-generation sequencing; neuro-muscular disorders; myopathies; muscular dystrophies; neurodevelopmental disorders; Tourette syndrome
Interests: clinical neuroscience; Tourette syndrome; obsessive compulsive disorder; Tourette associations networking
Special Issue Information
Dear Colleagues,
Gilles de la Tourette syndrome (GTS) is a developmental neuropsychiatric disorder characterized by multiple involuntary motor and vocal tics. The clinical phenotype of GTS belongs to the spectrum of tic disorders (TDs). Moreover, up to 85% GTS patients present a variety of additional symptoms due to psychiatric comorbidities, including attention-deficit and hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD), autism spectrum disorder (ASD), affective disorders, anxiety disorders, impulse control disorders, and personality disorders, implying an overlapping etiology.
The estimated GTS prevalence is approximately 1%; however, other, non-GTS TDs are more common than GTS and affect up to 5% of the general population. In general, GTS and TDs have a significant genetic component, with the heritability estimated at 60–80%. However, the clinical phenotype may be influenced by environmental, prenatal, and perinatal factors, hormonal disturbances, and interactions with multiple proteins.
Authors are invited to submit research articles and reviews on related topics, which will improve our understanding of the etiology and pathomechanism of neuropsychiatric disorders. The topics may include, but are not limited to, genetics and genomics, molecular neurobiology, neuromolecular imaging, molecular experimental models, and treatment. Our Special Issue is mainly focused on molecular research. Therefore, we wish to avoid attracting pure clinical manuscripts. Please notice this point when you prepare your manuscript for submission to this Special Issue.
Dr. Jakub P. Fichna
Dr. Natalia Szejko
Guest Editors
Manuscript Submission Information
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Keywords
- Tourette syndrome
- genetics and genomics
- molecular neurobiology
