Dopamine Neurons and the Genetic Pharmacology of Addiction: Unraveling Molecular Pathways

Dear Colleagues,

We understand that addictive behavior seeking is a multi-faceted neurobiological, genetic, epigenetic, personality and spiritual phenomenon, which proves that addictions are not one-dimensional and their occurrence requires currently unknown accompanying factors.

Evidence of a significant degree of inheritance in all types of addictions has led to attempts to identify specific genes. Research is complicated by the fact that addictive behaviors are a complex trait that is heterogeneous in terms of phenotype and genetics. It is believed that the profile of symptoms and the variety of observed behaviors are influenced by numerous gene loci, which differ in the direction of influence and the intensity of the effect. The possibilities of understanding the genetic basis of addiction are further complicated by interactions between different loci (epistasis) and gene–environment interactions. Therefore, although substance abuse and addiction undoubtedly depend on genetic factors, the genetic cross-section of these disorders is more complicated than in the case of traits inherited according to Mendel’s laws.

Advances in genome technology are increasing the ability to unravel many of the complex aspects of substance use disorders, including the role of low-effect genes, and to consider gene–environment interactions. It is hoped that in the future, discoveries made through the use of gene identification techniques combined with the results of functional, developmental, and pharmacological studies of the identified genes will lead to progress in the field of addiction prevention and treatment.

This Special Issue is supervised by Dr. Jolanta Chmielowiec, assisted by our Topical Advisory Panel Member Dr. Kszysztof Chmielowiec (University of Zielona Góra).

Dr. Jolanta Chmielowiec
Guest Editor

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• dopamine
• neurons
• addiction
• gene
• personality traits
• molecular mechanisms