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Molecular Research in Human Stem Cells
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Molecular Research in Human Stem Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 28 June 2024 | Viewed by 395

Special Issue Editors

Dr. Carmen Ciavarella

E-Mail Website
Guest Editor
Laboratory of Clinical Pathology, Department of Medical and Surgical Sciences (DIMEC), S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Interests: mesenchymal stem cells; cardiovascular disease; atherosclerosis; microRNA; cell differentiation; endothelial to mesenchymal transition (End-MT); inflammation; PPAR-γ
Dr. Sabrina Valente

E-Mail Website
Guest Editor
Laboratory of Clinical Pathology, Department of Medical and Surgical Sciences (DIMEC), S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Interests: vascular; stem cells; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stem cells constitute a reservoir of pluripotent cells, capable of differentiating into multiple specialized cell types, and meanwhile, they are endowed with self-renewal to continue the stem cell niche. The stem cell differentiation process is tightly regulated at several levels, like the chemokine/growth factor amount within the microenvironment and the molecular switchers. In this category, transcription factors, signal transduction pathways, microRNA (miRNA) and epigenetics (i.e., DNA methylation, acetylation, phosphorylation) are critical fine tuners of stem cell behavior and phenotypes, including the malignant fate. Therefore, investigating the main mechanisms that govern stem cell biology and fate decision would be promising for translational purposes, bridging the gap between the therapeutic potential and the involvement of stem cells in human disease.

This Special Issue of IJMS will cover the molecular regulatory mechanisms that shape stem cell properties and phenotypes, including in the pathological setting. Biomolecular experiments exploring the transcriptional switchers and miRNAs in stem cell biology are welcome.

Dr. Carmen Ciavarella
Dr. Sabrina Valente
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • mesenchymal stem cells
  • miRNA
  • differentiation
  • self-renewal
  • inflammation
  • transcription factors
  • senescence
  • extracellular vesicles

Published Papers (1 paper)

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Research

17 pages, 4428 KiB  
Article
Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes
by Dragica Mićanović, Suzana Stanisavljević, Hanluo Li, Ivan Koprivica, Natalija Jonić, Ivana Stojanović, Vuk Savković and Tamara Saksida
Int. J. Mol. Sci. 2024, 25(11), 5974; https://doi.org/10.3390/ijms25115974 - 29 May 2024
Viewed by 191
Abstract
Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates their potential for preventing type 1 diabetes (T1D) in C57BL/6 mice. [...] Read more.
Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates their potential for preventing type 1 diabetes (T1D) in C57BL/6 mice. T1D was induced in C57BL/6 mice by repeated low doses of streptozotocin. moMSCORS were injected intravenously on weekly basis. moMSCORS reduced T1D incidence, the insulitis stage, and preserved insulin production in treated animals. moMSCORS primarily exerted immunomodulatory effects by inhibiting CD4+ T cell proliferation and activation. Ex vivo analysis indicated that moMSCORS modified the cellular immune profile within pancreatic lymph nodes and pancreatic infiltrates by reducing the numbers of M1 pro-inflammatory macrophages and T helper 17 cells and upscaling the immunosuppressive T regulatory cells. The proportion of pathogenic insulin-specific CD4+ T cells was down-scaled in the lymph nodes, likely via soluble factors. The moMSCORS detected in the pancreatic infiltrates of treated mice presumably exerted the observed suppressive effect on CD4+ through direct contact. moMSCORS alleviated T1D symptoms in the mouse, qualifying as a candidate for therapeutic products by multiple advantages: non-invasive sampling by epilation, easy access, permanent availability, scalability, and benefits of auto-transplantation. Full article
(This article belongs to the Special Issue Molecular Research in Human Stem Cells)
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