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Molecular and Cellular Advances in Atopic Diseases

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 13193

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Special Issue Editor

Dr. Beatriz Cabanillas

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Guest Editor

Department of Allergy, Research Institute Hospital 12 de Octubre (imas12), Avenida de Córdoba s/n, 28041 Madrid, Spain
Interests: atopic dermatitis; asthma; food allergy; allergic rhinitis; molecular mechanisms; cellular mechanisms; treatment; diagnosis; prevention

Special Issue Information

Dear Colleagues,

Atopic dermatitis, asthma, food allergy, and allergic rhinitis affect around one billion patients worldwide, and this prevalence is steadily increasing. The pathophysiology of atopic diseases is complex, and numerous factors have a direct impact on its molecular and cellular basis. Recent advances in the field of atopic diseases are allowing a deeper understanding of the pathophysiology, sensitization routes, and the roles that specific immune cells, receptors, and pathways have in the initiation, development, and regulation of atopic diseases.

This Special Issue aims to cover novel insights on the molecular and cellular bases of atopic dermatitis, asthma, food allergy, and allergic rhinitis, as well as novel findings on the regulation, treatment, diagnosis, and prevention of these atopic diseases.

Your contribution to this Special Issue, in which you are invited to share your findings and insights in the form of research articles, reviews, or case reports, will be a valuable asset and a compelling contribution that will have an important impact on the field of atopic disease research.

Dr. Beatriz Cabanillas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

atopic dermatitis
asthma
food allergy
allergic rhinitis
molecular mechanisms
cellular mechanisms
treatment
diagnosis
prevention

Published Papers (6 papers)

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Editorial

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7 pages, 821 KiB

Open AccessEditorial

Special Issue “Molecular and Cellular Advances in Atopic Diseases”

by Beatriz Cabanillas

Int. J. Mol. Sci. 2024, 25(9), 4856; https://doi.org/10.3390/ijms25094856 - 29 Apr 2024

Viewed by 286

Abstract

Atopic diseases, which currently affect around one billion people worldwide, are experiencing a rising prevalence [...] Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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Research

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17 pages, 3125 KiB

Open AccessArticle

Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

by Ruperto González-Pérez, Paloma Poza-Guedes, Fernando Pineda, Tania Galán, Elena Mederos-Luis, Eva Abel-Fernández, María José Martínez and Inmaculada Sánchez-Machín

Int. J. Mol. Sci. 2023, 24(13), 10467; https://doi.org/10.3390/ijms241310467 - 21 Jun 2023

Cited by 6 | Viewed by 1967

Abstract

Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease. Although a complex repertoire of allergens was recognized, a steadily increasing number of IgE binding molecules was associated with the complexity of the underlying atopic disease. Besides the highly prevalent IgE responses to major HDM allergens, Der p 21, Der p 5, and Der p 7 also showed up as serodominant molecules, especially in subjects bothered by asthma and atopic dermatitis. The accurate characterization of the external exposome at the molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease in terms of personalized diagnosis and therapy. Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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15 pages, 6677 KiB

Open AccessArticle

NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis

by Ana B. Arroyo, Martín Bernal-Carrión, Joaquín Cantón-Sandoval, Isabel Cabas, Raúl Corbalán-Vélez, Teresa Martínez-Menchón, Belén Ferri, María L. Cayuela, Diana García-Moreno and Victoriano Mulero

Int. J. Mol. Sci. 2023, 24(9), 7992; https://doi.org/10.3390/ijms24097992 - 28 Apr 2023

Cited by 2 | Viewed by 2157

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease of very high prevalence, especially in childhood, with no specific treatment or cure. As its pathogenesis is complex, multifactorial and not fully understood, further research is needed to increase knowledge and develop new targeted therapies. We have recently demonstrated the critical role of NAD⁺ and poly (ADP-ribose) (PAR) metabolism in oxidative stress and skin inflammation. Specifically, we found that hyperactivation of PARP1 in response to DNA damage induced by reactive oxygen species, and fueled by NAMPT-derived NAD⁺, mediated inflammation through parthanatos cell death in zebrafish and human organotypic 3D skin models of psoriasis. Furthermore, the aberrant induction of NAMPT and PARP activity was observed in the lesional skin of psoriasis patients, supporting the role of these signaling pathways in psoriasis and pointing to NAMPT and PARP1 as potential novel therapeutic targets in treating skin inflammatory disorders. In the present work, we report, for the first time, altered NAD⁺ and PAR metabolism in the skin of AD patients and a strong correlation between NAMPT and PARP1 expression and the lesional status of AD. Furthermore, using a human 3D organotypic skin model of AD, we demonstrate that the pharmacological inhibition of NAMPT and PARP reduces pathology-associated biomarkers. These results help to understand the complexity of AD and reveal new potential treatments for AD patients. Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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15 pages, 2410 KiB

Open AccessArticle

The Anti-Atopic Dermatitis Effects of Mentha arvensis Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice

by So-Yeon Kim, Arjun Sapkota, Young Joo Bae, Seung-Hyuk Choi, Ho Jung Bae, Hyun-Jeong Kim, Ye Eun Cho, Yu-Yeong Choi, Ju-Yeon An, So-Young Cho, Sun Hee Hong, Ji Woong Choi and Se Jin Park

Int. J. Mol. Sci. 2023, 24(9), 7720; https://doi.org/10.3390/ijms24097720 - 23 Apr 2023

Cited by 4 | Viewed by 1934

Abstract

The NLRP3 inflammasome is upregulated by various agents, such as nuclear factor-kappa B (NF-κB), lipopolysaccharide (LPS), and adenosine triphosphate (ATP). The NLRP3 inflammasome facilitations the maturation of interleukin (IL)-1β, a proinflammatory cytokine that is critically involved in the pathogenesis of atopic dermatitis (AD). Although the NLRP3 inflammasome clearly exacerbates AD symptoms such as erythema and pruritus, drugs for AD patients targeting the NLRP3 inflammasome are still lacking. Based on the previous findings that Mentha arvensis essential oil (MAEO) possesses strong anti-inflammatory and anti-AD properties through its inhibition of the ERK/NF-κB signaling pathway, we postulated that MAEO might be capable of modulating the NLRP3 inflammasome in AD. The aim of this research was to investigate whether MAEO affects the inhibition of NLRP3 inflammasome activation in murine bone marrow-derived macrophages (BMDMs) stimulated with LPS + ATP in vitro and in a murine model displaying AD-like symptoms induced by 2,4-dinitrochlorobenzene (DNCB) in vivo. We found that MAEO inhibited the expression of NLRP3 and caspase-1, leading to the suppression of NLRP3 inflammasome activation and IL-1β production in BMDMs stimulated with LPS + ATP. In addition, MAEO exhibited efficacy in ameliorating AD symptoms in a murine model induced by DNCB, as indicated by the reduction in dermatitis score, ear thickness, transepidermal water loss (TEWL), epidermal thickness, and immunoglobulin E (IgE) levels. Furthermore, MAEO attenuated the recruitment of NLRP3-expressing macrophages and NLRP3 inflammasome activation in murine dorsal skin lesions induced by DNCB. Overall, we provide evidence for the anti-AD effects of MAEO via inhibition of NLRP3 inflammasome activation. Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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Review

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33 pages, 1366 KiB

Open AccessReview

Tools for Etiologic Diagnosis of Drug-Induced Allergic Conditions

by Rosa Rodríguez-Pérez, Leticia de las Vecillas, Rosario Cabañas and Teresa Bellón

Int. J. Mol. Sci. 2023, 24(16), 12577; https://doi.org/10.3390/ijms241612577 - 8 Aug 2023

Cited by 2 | Viewed by 1934

Abstract

Drug hypersensitivity reactions are a serious concern in clinical practice because they can be severe and result in lifelong sequelae. An accurate diagnosis and identification of the culprit drug is essential to prevent future reactions as well as for the identification of safe treatment alternatives. Nonetheless, the diagnosis can be challenging. In vivo and in vitro tests can be helpful, although none are conclusive; therefore, the tests are not usually performed in isolation but as part of a diagnostic algorithm. In addition, some in vitro tests are only available in research laboratories, and standardization has not been fully accomplished. Collaborating research is needed to improve drug hypersensitivity reaction diagnosis. In this review, we update the current available in vivo and in vitro tools with their pros and cons and propose an algorithm to integrate them into clinical practice. Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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11 pages, 815 KiB

Open AccessReview

Relative Humidity and Its Impact on the Immune System and Infections

by Gabriella Guarnieri, Bianca Olivieri, Gianenrico Senna and Andrea Vianello

Int. J. Mol. Sci. 2023, 24(11), 9456; https://doi.org/10.3390/ijms24119456 - 29 May 2023

Cited by 10 | Viewed by 4251

Abstract

Relative humidity (RH) represents an underestimated outdoor and indoor environmental parameter. Conditions below and above the optimal range could facilitate infectious transmission as well as the exacerbation of respiratory diseases. The aim of this review is to outline the consequences for health of suboptimal RH in the environment and how to limit this negative impact. RH primarily affects the rheological properties of the mucus, modifying its osmolarity and thus the mucociliary clearance. The integrity of the physical barrier, maintained by mucus and tight junctions, is critical for protection from pathogens or irritants. Moreover, the control of RH seems to be a strategy to prevent and control the spread of viruses and bacteria. However, the imbalance of RH in the outdoor and indoor environments is frequently associated with the presence of other irritants, allergens, and pathogens, and therefore the burden of a single risk factor is not clearly defined in different situations. Nonetheless, RHmay have a synergistic negative effect with these risk factors, and its normalization, if possible, may have a positive impact on a healthier environment. Full article

(This article belongs to the Special Issue Molecular and Cellular Advances in Atopic Diseases)

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