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Neuroplasticity Unveiled: Mechanisms across Neural Networks
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Neuroplasticity Unveiled: Mechanisms across Neural Networks

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 482

Special Issue Editor

Dr. Irina I. Stoyanova

E-Mail Website
Guest Editor
School of Medicine, Frankfurt Branch, European University Cyprus, Frankfurt am Main, Germany
Interests: neuronal network; neuron; neuroplasticity

Special Issue Information

Dear Colleagues,

This Special Issue intends to tackle the complicated mechanisms of neuroplasticity across multiple disciplines of neuroscience. Virtual and augmented reality technologies, for example, provide novel paradigms for researching cognitive processes, rendering a distinct viewpoint on neuroplasticity. In this respect, the cellular and molecular mechanisms associated with neuroplasticity changes in pathological circumstances constitute an essential part of neurodegeneration. We aim to particularly emphasize contributions illustrating adaptive and harmful alterations in neural networks throughout brain development and disease. Researchers interested in these dynamic subjects are therefore encouraged to contribute.

This Special Issue will serve as a forum for synthesizing knowledge from many subfields, encouraging collaboration, and furthering our understanding of the role of brain plasticity in health and disease. We also urge academics from all disciplines to contribute their ideas, comments, reviews, and original studies in order to create a comprehensive understanding of neuroplasticity across neural networks. Focus areas include, but are not limited to, extended reality in cognitive neuroscience, neurodegenerative molecular neurobiology, and neuroplasticity throughout brain development and disease.

Dr. Irina I. Stoyanova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroplasticity
  • extended reality
  • cognitive neuroscience
  • molecular neurobiology
  • neurodegeneration
  • brain development
  • neural networks
  • synaptic plasticity
  • neurorehabilitation
  • neuroadaptive changes

Published Papers (1 paper)

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Research

14 pages, 1452 KiB  
Article
Exploring the Role of MMP-9 and MMP-9/TIMP-1 Ratio in Subacute Stroke Recovery: A Prospective Observational Study
by Lidia Włodarczyk, Natalia Cichon, Michał Seweryn Karbownik, Joanna Saluk and Elzbieta Miller
Int. J. Mol. Sci. 2024, 25(11), 5745; https://doi.org/10.3390/ijms25115745 - 25 May 2024
Viewed by 222
Abstract
Despite the significant changes that unfold during the subacute phase of stroke, few studies have examined recovery abilities during this critical period. As neuroinflammation subsides and tissue degradation diminishes, the processes of neuroplasticity and angiogenesis intensify. An important factor in brain physiology and [...] Read more.
Despite the significant changes that unfold during the subacute phase of stroke, few studies have examined recovery abilities during this critical period. As neuroinflammation subsides and tissue degradation diminishes, the processes of neuroplasticity and angiogenesis intensify. An important factor in brain physiology and pathology, particularly neuroplasticity, is matrix metalloproteinase 9 (MMP-9). Its activity is modulated by tissue inhibitors of metalloproteinases (TIMPs), which impede substrate binding and activity by binding to its active sites. Notably, TIMP-1 specifically targets MMP-9 among other matrix metalloproteinases (MMPs). Our present study examines whether MMP-9 may play a beneficial role in psychological functions, particularly in alleviating depressive symptoms and enhancing specific cognitive domains, such as calculation. It appears that improvements in depressive symptoms during rehabilitation were notably linked with baseline MMP-9 plasma levels (r = −0.36, p = 0.025), and particularly so with the ratio of MMP-9 to TIMP-1, indicative of active MMP-9 (r = −0.42, p = 0.008). Furthermore, our findings support previous research demonstrating an inverse relationship between pre-rehabilitation MMP-9 serum levels and post-rehabilitation motor function. Crucially, our study emphasizes a positive correlation between cognition and motor function, highlighting the necessity of integrating both aspects into rehabilitation planning. These findings demonstrate the potential utility of MMP-9 as a prognostic biomarker for delineating recovery trajectories and guiding personalized treatment strategies for stroke patients during the subacute phase. Full article
(This article belongs to the Special Issue Neuroplasticity Unveiled: Mechanisms across Neural Networks)
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