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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Primary Graft Dysfunction and Acute Rejection in Solid Organ Transplantation
edited by
submission deadline 30 May 2024 | Viewed by 134 | Submission Open
Keywords: transplant; graft dysfunction; ischemia– reperfusion injury; DAMPs; immune cells; allo-antigens; acute rejection; metabolism; cell death; MHC; PRRs
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Pharmacogenetics
edited by Stefania Cheli
submission deadline 30 May 2024 | Viewed by 115 | Submission Open
Keywords: pharmacogenetics; pharmacokinetics; pharmacodynamics; genotype; haplotype; biomarker; single-nucleotide polymorphism; genomic variant; genetic testing; adverse drug reactions; clinical implementation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research on Vitamin D Metabolism in Disease
edited by Arnaud Molin
submission deadline 30 May 2024 | Viewed by 111 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D metabolizing enzyme; vitamin D metabolism; vitamin D regulation; calcium– phosphate homeostasis; cell differenciation; cell proliferation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Biofilms in Host Immune Responses and Antimicrobial Therapy
edited by Mayri Alejandra Díaz De Rienzo
submission deadline 30 May 2024 | Viewed by 110 | Submission Open
Keywords: biofilms; immune response; antimicrobial resistance; disruption; quorum sensing; host interactions
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Hypertension and Cardiovascular Disease
edited by Edyta Zbroch
submission deadline 31 May 2024 | 7 articles | Viewed by 24802 | Submission Open
Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-alcoholic Fatty Liver Disease (NAFLD) submission deadline 31 May 2024 | 9 articles | Viewed by 17110 | Submission Open
Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid-lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops
edited by
submission deadline 31 May 2024 | 8 articles | Viewed by 14878 | Submission Open
Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanisms and Means of Immune Modulation in Innate and Adaptive Immunity submission deadline 31 May 2024 | 7 articles | Viewed by 11841 | Submission Open
Keywords: immune checkpoints; innate immunity; adaptive immunity; modulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Breeding for Abiotic Stress Tolerance in Crops
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 11492 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses; plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Active Compounds from Foods: Applications in Antioxidant and Bioactivity Evaluation submission deadline 31 May 2024 | 7 articles | Viewed by 10940 | Submission Open
Keywords: polyphenols; omega-3 fatty acids; gelatin; fucoidans; chitosan; chondroitin sulfate; enzyme; antioxidant; anti-inflammatory
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Dendritic Cell and Cancer Therapy 2.0
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 10908 | Submission Open
Keywords: dendritic cells; dendritic cell subsets; cancer immunotherapy; immune suppression; cancer vaccines; anti-cancer response; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Targeting CAR T-cell Therapy: Molecular Research and Its Future Implication
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 10547 | Submission Open
Keywords: CAR T-cell therapy; malignant diseases; molecular pathways; CAR T-related toxicities; resistance mechanisms
(This special issue belongs to the Section Molecular Immunology)
Nanoparticles in Nanobiotechnology and Nanomedicine
edited by
submission deadline 31 May 2024 | 9 articles | Viewed by 10039 | Submission Open
Keywords: nanoparticles; properties of nanoparticles; methods of  obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Retinal Diseases: From Molecular Pathology to Therapies
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 9789 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; Stargardt disease; cone-rod dystrophy; Leber congenital amaurosis; best vitelliform macular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics and Multi-Omics for Crop Breeding submission deadline 31 May 2024 | 7 articles | Viewed by 9517 | Submission Open
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Basis of Extracellular Vesicles in Health and Diseases
edited by Taral R. Lunavat
submission deadline 31 May 2024 | 6 articles | Viewed by 9199 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Dopamine in Health and Disease: Biological Aspect 2.0 submission deadline 31 May 2024 | 7 articles | Viewed by 8400 | Submission Open
Keywords: dopamine; addiction; neurophysiology; dopaminergic system; neurotransmitter
(This special issue belongs to the Section Molecular Neurobiology)
Hormone Signaling in Cancers and Cancer-Promoting Pathologies
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 7978 | Submission Open
Keywords: estrogen; androgen; thyroxine; thyroid hormones; adrenalin; adrenocorticoids; progesterone; medroxyprogesterone; mifepristone; corticosteroids; glucocorticoids; mineralocorticoids; testosterone; cortisol; prednisolone; hormones; hormone receptors; endocrine-related cancers; hormone therapy; hormone therapy resistance; drug resistance; epigenetics; microRNA
(This special issue belongs to the Section Molecular Oncology)
Regulation and Targeting of Ferroptosis in Tumor and Beyond
edited by and Jin Xie
submission deadline 31 May 2024 | 5 articles | Viewed by 7711 | Submission Open
Keywords: ferroptosis; iron; tumor survival and cell death; oxidation; drug development; anticancer strategies
(This special issue belongs to the Section Molecular Oncology)
Antibacterial Strategies in Biomaterials: Current Progress and Challenges 2.0
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 7637 | Submission Open
Keywords: nanobiomaterials; antimicrobial nanoparticles; biofilm modulation; surfaces and coatings to control bacterial attachment; molecules and nanodrugs; drug delivery; multifunctional materials; infection control; vaccines for drug resistant bacteria
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Somatic Cell Cloning and Other Assisted Reproductive Technologies in Mammals submission deadline 31 May 2024 | 5 articles | Viewed by 7598 | Submission Open
Keywords: somatic cell nuclear transfer (SCNT); SCNT-based cloning; assisted reproductive technology (ART); in vitro embryo production (IVP); in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); in vivo embryo production
(This special issue belongs to the Section Molecular Biology)
Cutaneous Biology, Molecular Dermatology and Dermatopathology
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 7447 | Submission Open
Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 7353 | Submission Open
Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Diagnostics and Therapeutic Target in Bladder Cancer
edited by Hideki Furuya
submission deadline 31 May 2024 | 6 articles | Viewed by 6976 | Submission Open
Keywords: non-muscle invasive bladder cancer; muscle invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Omics and Artificial Intelligence for the Personalized Management of Inflammatory and Neoplastic Digestive Diseases submission deadline 31 May 2024 | 3 articles | Viewed by 6484 | Submission Open
Keywords: systems medicine; big data; data harmonization and integration; artificial intelligence; inflammatory digestive diseases; neoplastic digestive diseases
(This special issue belongs to the Section Molecular Informatics)
Oral Soft Tissue Repair and Oral Diseases
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 6410 | Submission Open
Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Biology)
Biomolecular Structure, Function and Interactions
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 5919 | Submission Open
Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability
(This special issue belongs to the Section Biochemistry)
Design, Synthesis, and Mechanism of Fluorescent and Luminescent Materials submission deadline 31 May 2024 | 5 articles | Viewed by 5914 | Submission Open
Keywords: luminiscent materials; molecular design and synthesis; supramolecular chemistry; emissive mechanisms and processes; photophysics; photochemistry; probes and sensors; optoelectronics
(This special issue belongs to the Section Materials Science)
Fifty Years of Targeted Therapy in Cancer: Past, Present and Future
edited by
submission deadline 31 May 2024 | 3 articles | Viewed by 5848 | Submission Open
Keywords: tumor microenvironment; immune suppression; targeted therapy; immune checkpoint blockers; epigenetic regulators; macrophage polarization; cancer stem cells; therapeutic resistance; tumor immune microenvironment; immunotherapy; repurposed drugs; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Computer-Aided Drug Design Strategies
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 5795 | Submission Open
Keywords: artificial intelligence; machine learning; cheminformatics; docking; molecular dynamics; homology modeling; pharmacophore modeling; QSAR; ligand-based similarity
(This special issue belongs to the Section Molecular Informatics)
Wound Repair and Regeneration 2023
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 5767 | Submission Open
Keywords: wound healing; inflammation; scarring; extracellular matrix; regeneration; biomaterials; chronic wounds; remodeling; stem cells; growth factors; disease; pathophysiology; therapy; tissue engineering
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Neurodevelopmental Disorders
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 5676 | Submission Open
Keywords: neurodevelopmental disorders; genetics; molecular pathways; neural development; neurogenesis; animal models
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Progress and Application of Photodynamic Therapy submission deadline 31 May 2024 | 3 articles | Viewed by 5476 | Submission Open
Keywords: photodynamic therapy; photobiology; light sources; illumination; light emitting diodes (LED); laser; photosensitizer; methylamoninolevunlic acid; delta aminolevulinic acid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Extracellular Matrix Proteins in Pathogenesis
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 5366 | Submission Open
Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism of Cancer Research and Therapies
edited by
submission deadline 31 May 2024 | 3 articles | Viewed by 5354 | Submission Open
Keywords: molecular mechanism; multistate model; cancer; precsion cancer care; preventive and therapeutic care
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Epigenetic Modifications
edited by , Mariella Cuomo and
submission deadline 31 May 2024 | 2 articles | Viewed by 5293 | Submission Open
Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Antimicrobial and Antiviral Nanoparticles  submission deadline 31 May 2024 | 2 articles | Viewed by 5223 | Submission Open
Keywords: nanotechnology; antibiotic; resistance; nanostructure; pharmaceutical and environmental applications; remediation; green synthesis; sustainability; oxidative stress; photocatalytic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Ionic Liquids and Their Pharmaceutical Applications submission deadline 31 May 2024 | 3 articles | Viewed by 5150 | Submission Open
Keywords: ionic liquid; active pharmaceutical ingredient; drug delivery; human toxicity; environmental impact; pharmaceutical industry; pharmaceutical efficiency
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
New Insight into Signaling and Autophagy in Plants 3.0 submission deadline 31 May 2024 | 3 articles | Viewed by 5034 | Submission Open
Keywords: autophagy cargo receptors; autophagy in plant development; autophagy in plant stress; crosstalk between autophagy and phytohormones; plant cell homeostasis; nutrients recycling; plant cell biology; plant signal transduction; selective autophagy; signaling molecules
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Genome Editing
edited by Lei Gao
submission deadline 31 May 2024 | 4 articles | Viewed by 4891 | Submission Open
Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Omics: Sensing, Signaling, Regulation and Homeostasis submission deadline 31 May 2024 | 5 articles | Viewed by 4762 | Submission Open
Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology
(This special issue belongs to the Section Molecular Plant Sciences)
Antiviral Activities of Plant Extracts
edited by
submission deadline 31 May 2024 | 3 articles | Viewed by 4654 | Submission Open
Keywords: plant extracts; secondary metabolites; metabolomics; antiviral activity; human viruses; SARS-CoV-2; animal viruses; phytochemical composition; medicinal substances
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Proteomics and Its Applications in Human Biology
edited by
submission deadline 31 May 2024 | 3 articles | Viewed by 4649 | Submission Open
Keywords: proteins; post-translational modifications; immune system; inflammasome; biomarkers; imaging proteomics; disease; cancer immunology; immune cross-talk; patient care; immunotherapy; autoimmune disorder
(This special issue belongs to the Section Molecular Immunology)
Properties and Applications of Metal-Organic Frameworks
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 4593 | Submission Open
Keywords: metal-organic frameworks; molecular simulation; high-throughput computational screening; machine learning; structure-property relationship; adsorption
(This special issue belongs to the Section Materials Science)
Molecular Analysis of Plant–Pathogen Interaction submission deadline 31 May 2024 | 5 articles | Viewed by 4525 | Submission Open
Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides  
(This special issue belongs to the Section Molecular Microbiology)
Retinal Degeneration—From Genetics to Therapy 2.0 submission deadline 31 May 2024 | 4 articles | Viewed by 4476 | Submission Open
Keywords: ophthalmology; inherited retinal dystrophies; retinal degeneration; genetics; natural history studies; gene augmentation; gene editing; reprogramming; optogenetics and splice modulation therapy; animal models; human iPSC-derived retina and retinal pigment epithelium
(This special issue belongs to the Section Molecular Biology)
New Molecular Mechanisms and Advanced Therapies for Solid Tumors
edited by
submission deadline 31 May 2024 | 2 articles | Viewed by 4385 | Submission Open
Keywords: solid tumor; kinase inhibitors; animal model; cell culture; drug resistance; signal transduction; survival; cell reprogramming; pathways; clinical trials; target therapy; cell cycle; cell death inhibiting; oncogene; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Eosinophilic Esophagitis: Molecular Mechanisms, Diagnosis, and Therapeutic Strategies
edited by Francesca Racca and Gaia Pellegatta
submission deadline 31 May 2024 | 3 articles | Viewed by 4363 | Submission Open
Keywords: real-world data; esophageal delivery; non-invasive diagnostic methodologies; molecular mechanisms; therapeutic strategies; comorbidities; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Mechanisms of Biofilms submission deadline 31 May 2024 | 4 articles | Viewed by 4190 | Submission Open
Keywords: bacterial biofilms; implant infections; infection and immunity; biofilm matrix; biofilm matrix macromolecular components; extracellular DNA; biofilm associated proteins; biofilm polysaccharides; inflammation; anti-biofilm molecules; anti-biofilm biomaterials
(This special issue belongs to the Section Molecular Microbiology)
AMP-Activated Protein Kinases in Health and Disease
edited by
submission deadline 31 May 2024 | 2 articles | Viewed by 4169 | Submission Open
Keywords: AMPK; inflammation; cancer; cardiovascular diseases; metabolic diseases; oxidative stress; phytochemicals
(This special issue belongs to the Section Biochemistry)
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