Metal-Based Compounds: Relevance for the Biomedical Field
A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".
Deadline for manuscript submissions: 15 September 2024 | Viewed by 7339
Special Issue Editors
Interests: chemistry of transition metal complexes; nanoparticles as drug delivery systems; antitumor activity
Interests: transition metal chemistry; biomolecules interactions; antitumor activity
Special Issue Information
Dear Colleagues,
The exciting research fields of Bioinorganic chemistry and Inorganic medicinal chemistry are in full expansion, providing new perspectives regarding the interaction of inorganic compounds with biological matrixes and their potential as therapeutic and diagnosis agents. Metal complexes, especially those containing transition metal ions, are valuable platforms for drug design and have proven their biological properties many times over, with important progress being made in obtaining new compounds with antitumor, antibacterial, antiviral and antifungal activity.
This Inorganics Special issue wishes to provide an overview on the current topics of interest in Inorganic chemistry with a focus on bioactive compounds. Original research articles as well as reviews are welcome, with the aim to highlight recent advances concerning the following issues:
- The role of metal ions in biological environments
- Synthesis, phisico-chemical characterization of metal complexes and evaluation of their biological and therapeutic potential
- The interaction of coordination and organometallic compounds with biological macromolecules, such as nucleic acids and proteins
- Coordination compounds as metallo-enzymes mimics
- Metallic and metal oxide nanoparticles as therapeutic and diagnosis agents
Dr. Tamara Topala
Prof. Dr. Luminita Simona Oprean
Dr. Andreea Elena Bodoki
Guest Editors
Manuscript Submission Information
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Keywords
- transition metal complexes
- biomolecules interactions
- enzyme mimics
- therapeutic platforms
- diagnosis agents
- biological activity
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Evaluation of DNA and BSA binding, nuclease activity and anticancer properties of new Cu(II) and Ni(II) complexes with quinoline derived sulfonamides
Authors: Tamara Liana Topală; Ionel Fizeșan; Andreea Elena Petru; Alfonso Castiñeiras; Andreea Elena Bodoki; Luminița Simona Oprean; Marcos Escolano; Gloria Alzuet–Piña
Affiliation: Department of Inorganic Chemistry, Faculty of Pharmacy, Universitat de València, Valencia, Spain
Abstract: Four complexes of essential metal ions, Cu(II) and Ni(II), with the new sulfonamide ligand N-(pyridin-2-ylmethyl)quinoline-8-sulfonamide (HQSMR) were synthesized and physicochemically and structurally characterized. Complex [Cu(QSMR)Cl]n (2) consists in a polymeric chain formed by distorted square pyramidal units. In 2 the sulfonamide ligand acts as a bridge coordinating to one Cu(II) through its three N atoms and to another metal ion via one O atom of the sulfonamido group, while the pentacoordinate complex [Cu(QSMR)(C6H5COO)] (3) presents a highly distorted square pyramidal geometry. Complex [Ni(QSMR)(C6H5COO)(CH3OH)][Ni(QSMR)(CH3COO)(CH3OH)] (4) consists in two mononuclear entities, containing different anion coligands, either a benzoate or an acetate group. Both units exhibit a distorted octahedral geometry. The interaction of the complexes with CT-DNA was studied by means of UV-Vis and fluorescence spectroscopy, interestingly revealing that the Ni(II) complex presents the highest affinity towards the nucleic acid. Complexes 1 and 2 are able to cleave DNA. Both compounds show promising nuclease activity at relatively low concentrations, by mediating the production of reactive oxygen species (ROS). The interaction of the four complexes with bovine serum albumin (BSA) was also investigated, showing that the compounds can bind to serum proteins. The antitumor potential of complexes 1 and 2 was evaluated against the A549 lung adenocarcinoma cell line, revealing cytotoxic properties that were both dose and time dependent.
Title: Green-Synthesized Zinc Oxide/Silver Nanoparticles from Sophora pachycarpa for Anticancer Activity, Gene Expression Analysis, and Antibacterial Applications
Authors: Sobhan Mortazavi-Derazkola
Affiliation: Birjand University of Medical Sciences
Title: Zinc complexes to model zinc enzyme active sites, and comparing the small molecule Zn species with docking and enzyme inhibition assay
Authors: Kyle A. Grice
Affiliation: Department of Chemistry and Biochemistry, College of Science and Health, DePaul University, Chicago, IL 60614, USA
Abstract: Zinc complexes to model zinc enzyme active sites, and comparing the small molecule Zn species with docking and enzyme inhibition assay
Title: Exploring the Antibacterial, Antifungal, Antiradical Properties, and Structural Insights of Copper(II) and Nickel(II) Complexes with New 1-(Morpholin-4-yl)propan-1,2-dione 4-Allylthiosemicarbazone
Authors: Ianina Graur; Vasilii Graur; Marina Cadin; Olga Garbuz; Pavlina Bourosh; Elena Melnic; Carolina Lozan-Tirsu; Greta Balan; Victor Tsapkov; Aurelian Gulea
Affiliation: Laboratory of Advanced Materials in Biofarmaceutics and Technics, Institute of Chemistry, Moldova State University, 60 Mateevici Street, MD 2009, Chisinau, Moldova
Abstract: The eleven new copper(II) and nickel(II) coordination compounds [Cu(L)Br]2 (1), [Cu(L)Cl] (2), [Cu(L)NO3] (3), [Ni(L)Cl] (4), [Ni(HL)2](NO3)2 (5), and [Cu(A)(L)]NO3,where A is 1,10-phenanthroline (6), 2,2’-bipyridine (7), 3,4-dimethylpyridine (8), 3-methylpyridine (9), pyridine (10) or imidazole (11) were synthesized with 1-(morpholin-4-yl)propan-1,2-dione 4-allylthiosemicarbazone (HL). The new thiosemicarbazone was characterized by NMR, and FTIR spectroscopy. All the coordination compounds were characterized by elemental analysis and FTIR spectroscopy. Also, the crystal structures of HL and complexes 1, 6, 7, 11 were determined using single-crystal X-ray diffraction analysis. Complex 1 has a dimeric molecular structure with two bromide bridging ligands while 6, 7 and 11 are ionic compounds and comprise monomeric complex cations. The studied complexes manifest antibacterial and antifungal activities, and also have an antiradical activity that in many cases surpasses the activity of trolox which is used as standard antioxidant in medicine. Copper complexes 1-3 have a very weak antiradical properties (IC50 > 100 µM), but nickel complexes 4-5 are strong antiradicals with IC50 values lower than that of trolox. The mixed ligand copper complexes with additional ligand of N-heteroaromatic base are superior to complexes without these additional ligands. They are 1.4-5 times more active than trolox.