Prevention and Treatment of Gastric Cancer
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 1787
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gastric cancer is the 5th most common cancer and the 4th leading cause of cancer-associated death worldwide. Its five-year survival is as low as 21.6% in the UK due to late diagnosis and a limited number of effective treatments. Additionally, 43% of patients have stage IV disease when diagnosed. The symptoms of early gastric cancer are vague and non-specific, including dyspepsia. Typical ‘red flags,’ signs that prompt patients to see their doctor, such as a palpable upper abdominal mass, dysphagia, vomiting and weight loss, are more consistent with advanced and even metastatic disease. Therefore, the early diagnostic testing and risk stratification of patients more susceptible to gastric cancer may help identify the disease at an earlier stage, potentially increasing the chances of recovery. Although there are no interventions currently employed to prevent gastric cancer, lifestyle measures may reduce its risk. These include reducing excess alcohol consumption, not smoking, and bringing one’s BMI to within a healthy range. Patients with early disease (T1a) may undergo endoscopic resection. More advanced but curative cases may undergo radical surgical resection and D2 lymphadenectomy with perioperative chemotherapy. Breakthroughs in the immune profiling of tumours, such as mismatch repair deficiency and microsatellite instability, enable patients to potentially benefit from immunotherapy. This may be given concurrently with chemotherapy to improve the overall and recurrence-free survival. Further research on its early diagnosis, risk stratification and systemic therapies are required in order to improve the outcomes of this disease.
Dr. Sacheen Kumar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- early diagnosis
- risk stratification
- lifestyle modification
- perioperative chemotherapy
- D2 lymphadenectomy
- gas-tric adenocarcinoma
- biomarkers