New Insights into Pediatric Asthma

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Pediatrics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 3770

Special Issue Editor


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Guest Editor
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
Interests: severe asthma; paediatric asthma; biologics; asthma risk prediction; early intervention; real-world evidence

Special Issue Information

Dear Colleagues,

Pediatric asthma is a complex heterogenous inflammatory disease characterized by varied phenotypes and endotypes, of which the natural history is not well understood. Asthma management in children is in particular challenging due to limitations to the assessment of asthma, selection of initial long-term control medication, appropriate dosing and patient cooperation. Early interventions and long-term treatment with inhaled steroids, nonsteroid controller medications and biologicals may offer new opportunities to control the development of asthma; however, the potential effects and risks over time require careful investigation. With the rapid advances in genomic medicine and big data technology, it is possible to develop precision medicine strategies for more accurate characterization of asthma phenotypes, early prediction of asthma disposition, exacerbation risks and clinical outcomes, and tailored therapeutic intervention to address the need of individual patient at early stage.  Advances have also been taking place in the identification of key allergens and environmental control methods, digital health technologies to improve inhaler technique, medication adherence and home monitoring, as well as lifestyle inventions. To help healthcare professionals navigate the landscape of pediatric asthma, we are inviting a series of original and/or review articles that focus on its development, assessment, treatment, early intervention, environmental control and lifestyle intervention, precision medicine, e-Health and home monitoring approaches.

Dr. Wenjia Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric asthma
  • childhood asthma
  • childhood asthma management program
  • early intervention
  • long-term control therapy
  • phenotype
  • precision medicine
  • electronic health records
  • digital health
  • monitoring

Published Papers (1 paper)

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Research

31 pages, 463 KiB  
Article
Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group
by Valentina Fainardi, Carlo Caffarelli, Michela Deolmi, Giulia Zambelli, Elisabetta Palazzolo, Sara Scavone, Barbara Maria Bergamini, Luca Bertelli, Loretta Biserna, Paolo Bottau, Elena Corinaldesi, Nicoletta De Paulis, Emanuela Di Palmo, Arianna Dondi, Marcella Gallucci, Battista Guidi, Francesca Lombardi, Maria Sole Magistrali, Elisabetta Marastoni, Silvia Pastorelli, Alessandra Piccorossi, Maurizio Poloni, Sylvie Tagliati, Francesca Vaienti, Giuseppe Gregori, Roberto Sacchetti, Francesco Antodaro, Andrea Bergomi, Lamberto Reggiani, Alessandro De Fanti, Federico Marchetti, Roberto Grandinetti, Nicole Mussi, Giampaolo Ricci and Susanna Espositoadd Show full author list remove Hide full author list
J. Clin. Med. 2023, 12(17), 5467; https://doi.org/10.3390/jcm12175467 - 23 Aug 2023
Viewed by 3559
Abstract
Asthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims [...] Read more.
Asthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims to summarize the most recent evidence regarding maintenance therapy for asthma in children and adolescents. A multidisciplinary panel of experts was asked clinical questions regarding the treatment of children and adolescents with asthma. Overall, 10 clinical questions were addressed, and the search strategy included accessing electronic databases and a manual search of gray literature published in the last 25 years. After data extraction and narrative synthesis of results, recommendations were developed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology. Results showed that the choice of medication depends on the severity of the child’s asthma, phenotype, age, preference, and individual factors. In addition to medications, the identification of comorbidities and modifiable factors is crucial to obtaining good control. Asthma in children is heterogeneous, and its evolution varies over time. Since most recommendations for asthma management in childhood are extrapolated from clinical studies performed in adults, more clinical trials specifically designed for young children should be conducted. Full article
(This article belongs to the Special Issue New Insights into Pediatric Asthma)
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