Immunoregulatory Metabolites with Clinical Relevance
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 2839
Special Issue Editors
Interests: immunometabolism; biochemical toxicology; redox biochemistry; aromatic amino acids; neopterin
Special Issues, Collections and Topics in MDPI journals
Interests: neopterin; kynurenine; biomarkers; cancer; immunotherapy
Interests: neopterin; tryptophan; kynurenine; analytical chemistry; biomarkers; immunobiochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Numerous metabolites significantly contribute to the regulation of immune responses. Their modes of action can vary widely, ranging from immune activation to the termination of inflammation, the suppression of responses, and the mediation of tolerance. A key example is cytokine interferon-gamma, which affects a variety of metabolic pathways. In this context, immune-mediated tryptophan catabolism along the kynurenine axis is probably one of the most reviewed metabolic pathways, with clinical relevance in chronic immunopathologies. However, several other metabolite classes are co-regulated with cytokine responses, linking, e.g., altered nutrient and energy metabolism to immunological processes relevant to disease. In this Special Issue, metabolites that influence immunological regulatory circuits and have clinical relevance, e.g., as potential drug targets, or with predictive or prognostic significance, are presented. These may include but are not limited to amino acids and derivatives, biogenic amines, lipid classes, pteridines, and signaling gases. Clinical and translational studies as well as basic experimental research will be covered.
Prof. Dr. Johanna M. Gostner
Prof. Dr. Bohuslav Melichar
Prof. Dr. Dietmar Fuchs
Guest Editors
Manuscript Submission Information
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Keywords
- immunometabolism
- (metabolite) biomarker
- immunoregulation
- crosstalk of immunity and metabolism
- clinical relevance
- immunobiochemistry