Diet, Gut Microbiota, and Gastrointestinal Disease

Dear Colleagues,

Gastrointestinal diseases are a significant cause of morbidity and mortality worldwide. The recent advent of metagenomic techniques has highlighted the important role of the gut microbiota in human pathology.

The gut provides a vast interface area for the interaction between the host and the intestinal microbiota. At this level, the intricate crosstalk involves bacteria, surface cells, immune cells, endothelial cells, and nervous terminals. Moreover, there are several possible mediators involved in these interactions, such as microbial products, cytokines, and signalling factors, which make the scenario even more complex.

In this intricate conundrum, recent evidence has highlighted that some mechanisms of carcinogenesis may be strictly linked to dysbiosis and the detrimental effects of a derangement in the gut microbiota metabolism. Diet is a crucial modulator of the gut microbiota, and thus, it can be both detrimental, increasing the risk of gastrointestinal diseases via a more inflammatory and unhealthy gut microbiota, as well as helpful in restoring a balance in the gut microenvironment, resulting in a protective effect on disease development.

The Special Issue “Diet, Gut Microbiota, and Gastrointestinal Disease” aims to provide a platform for researchers with a keen interest in the study of this dynamic topic, specifically the interplay between diet/nutritional supplements, gut microbiota, and gastrointestinal diseases including cancer. Original articles and reviews focusing on this topic are welcome.

Dr. Francesca Romana Ponziani
Guest Editor

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• gut microbiota
• diet
• dietary supplements
• inflammatory bowel diseases
• coeliac disease
• Helicobacter pylori
• autoimmune gastritis
• eosinophilic esophagitis
• Crohn disease
• ulcerative colitis
• diverticular disease
• irritable bowel syndrome
• autoimmune hepatitis
• viral hepatitis
• metabolic dysfunction-associated steatotic liver disease
• liver cancer
• biliary tract cancers
• pancreatic cancer
• gastric cancer
• esophageal cancer
• colon cancer
• host-microbiota interaction
• inflammation
• immunomodulation
• metabolomics
• personalized medicine