Plant Extracts and Their Cytotoxic Activities 2nd Edition

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 582

Special Issue Editors


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Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland
Interests: phytochemical analysis; structure–activity relationships; saponins; quinones; cytotoxic activity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland
Interests: cytotoxic activity studies; lichen metabolites; phytochemical analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite enormous therapeutic achievements, cancer diseases pose an ongoing threat to humans. The plant kingdom has always served as a reservoir of medicinal agents, and it still remains an important source for the acquisition of currently used modern drugs. Noteworthy is its significant contribution to chemotherapy, and currently applied treatment protocols include a substantial number of plant-derived anti-cancer drugs. The first step in the development of a potentially effective anti-cancer drugs of natural origin is the study of the cytotoxic activity of extracts derived from plants and other natural sources.

The first edition of this Special Issue dedicated to studies on the cytotoxic activity of extracts attracted a great deal of interest. We are therefore very pleased to announce the opening of its second edition. As was the case previously, the main objective is to collect original research papers, as well as review articles, addressing recent advances in the research on the cytotoxic activity of extracts derived from plant species. A wide variety of areas will be covered, including comparative analysis of extracts prepared with different methods, their chemical qualitative and quantitative characterization, their cytotoxic activity (including synergistic effects) in relation to the predominant compounds, and other topics. Studies that address advanced chemometric analysis are particularly welcome. In addition to higher plants, reports on the cytotoxic activity of extracts derived from fungal and lichen sources are also encouraged.

Dr. Irma Podolak
Dr. Agnieszka Galanty
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytotoxic activity
  • antiproliferative activity
  • bioactive compounds
  • extract profiling
  • qualitative/quantitative analysis

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Published Papers (1 paper)

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Research

18 pages, 2106 KiB  
Article
Can Simulated Microgravity and Darkness Conditions Influence the Phytochemical Content and Bioactivity of the Sprouts?—A Preliminary Study on Selected Fabaceae Species
by Marta Grudzińska, Agnieszka Galanty, Ewelina Prochownik, Agata Kołodziejczyk and Paweł Paśko
Plants 2024, 13(11), 1515; https://doi.org/10.3390/plants13111515 - 30 May 2024
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Abstract
Sprouts’ consumption has become popular due to their wide availability, easy cultivation process, and proven biological activity. Moreover, stress factors, such as limited access to light or disturbed gravity during growth, may contribute to the increased activity and the synthesis of bioactive compounds. [...] Read more.
Sprouts’ consumption has become popular due to their wide availability, easy cultivation process, and proven biological activity. Moreover, stress factors, such as limited access to light or disturbed gravity during growth, may contribute to the increased activity and the synthesis of bioactive compounds. In this study, for the first time, the examination of the impact of darkness and simulated microgravity conditions on the white clover sprouts from the Fabaceae family was conducted. Among several species, used in the preliminary attempts, only white clover was satisfactory sprouting in the disturbed gravity conditions, and thus was chosen for further examination. A random positioning machine setup was used during the cultivation process to simulate microgravity conditions. Additionally, the sprouts were cultivated in total darkness. Simulated microgravity and/or darkness during the first few days of the sprouts’ growth caused biomass reduction, the increased synthesis of bioactive compounds (isoflavones and phenolics), and changes in the level of abscisic acid and phenylalanine ammonia-lyase. Moreover, it increased the antioxidant properties of the sprouts, while the enhancement of their cytotoxic impact was observed only for androgen-dependent prostate cancer LNCaP cells. To conclude, the presented results are promising in searching for novel functional food candidates and further studies are necessary, directed at other plant families. Full article
(This article belongs to the Special Issue Plant Extracts and Their Cytotoxic Activities 2nd Edition)
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