Application and Chemical Characterization of Plant Natural Products

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2913

Special Issue Editor


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Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Università degli Studi di Palermo, I-90128 Palermo, Italy
Interests: essential oils chemical composition; plant chemistry

Special Issue Information

Dear Colleagues,

The plant kingdom is the main source of chemical diversity from which hundreds of organic molecular frameworks are produced, which means several thousands of compounds and hundreds of new molecules are discovered every day in industrial and academic laboratories around the world.

Nature still remains the most efficient and imaginative “synthetic chemist”, and this impressive mass of chemical knowledge is the grounds for the development of a potentially infinite number of new applications in the contexts of agriculture, food science, and pharmacology, without neglecting the very interesting new applications of plant products in the preservation of cultural heritage artefacts.

The isolation and chemical characterization of new complex structures remain fascinating challenges for natural product researchers.

The present Special Issue will be addressed mainly, but not exclusively, to presenting the most recent results concerning new applications (nutraceutical, biological, pharmacological, etc.) of plant extracts, essential oils, and pure compounds isolated from plants; the description of previously unknown phytochemical profiles of plant species; and the structural elucidation of non-banal new molecules from plant extracts.

Prof. Dr. Maurizio Bruno
Guest Editor

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Keywords

  • essential oils
  • plant extracts
  • bioactivity
  • new phytochemicals

Published Papers (3 papers)

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Research

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11 pages, 1842 KiB  
Article
The Biological Properties of the Essential Oil from the Jordan Accession of Phagnalon sinaicum Bornm. & Kneuck.
by Natale Badalamenti, Michela Di Napoli, Giusy Castagliuolo, Mario Varcamonti, Maurizio Bruno and Anna Zanfardino
Plants 2023, 12(23), 4007; https://doi.org/10.3390/plants12234007 - 28 Nov 2023
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Abstract
The genus Phagnalon Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well [...] Read more.
The genus Phagnalon Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well as the complex mixtures of their essential oils, from several Phagnalon species and ssp., have shown antibiotic, antiviral, cytotoxic, and several other biological properties. In this work, the chemical composition and the antimicrobial, cytotoxic, and antioxidant properties of the Jordan accession of Phagnalon sinaicum Bornm. & Kneuck. essential oil (EO), an extremely rare plant that grows in ravines in the Middle East, were investigated. The EO, analyzed by GC-MS, was found to be rich in terpenoid compounds, and, in particular, in oxygenated monoterpenes, with the main compound being artemisia ketone (22.3%), followed by α-thujone (17.7%), and santolin alcohol (14.8%). The EO had good antimicrobial activity, especially against Escherichia coli Gram-negative bacterium (3 mg/mL MIC values) and was also effective in counteracting in vitro biofilm formation. Furthermore, this EO showed low cytotoxicity against immortalized human keratinocytes lines, but had good antioxidant activity on the same eukaryotic cellular models. Full article
(This article belongs to the Special Issue Application and Chemical Characterization of Plant Natural Products)
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15 pages, 2146 KiB  
Article
Antioxidant Activity and Chemical Composition of Geranium Oil and Its Synergistic Potential against Pneumococci with Various Antibiotic Combinations
by Berrak Dumlupinar, Gökçe Şeker Karatoprak, Betül Demirci, Esra Küpeli Akkol and Eduardo Sobarzo-Sánchez
Plants 2023, 12(17), 3080; https://doi.org/10.3390/plants12173080 - 28 Aug 2023
Cited by 2 | Viewed by 1301
Abstract
The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In [...] Read more.
The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In addition, the second goal of this study was to determine whether the essential oil combined with various antibiotics increased the overall killing activity in mouse macrophage cells with the aim of introducing an immunotherapeutic approach to the infection treatments used today. Herein, the volatile profile of Geranium oil (G.O) was analyzed using GC/MS. The current study sought to assess the synergistic characteristics of several antibiotic combinations using G.O against pneumococci, as well as the oil’s antioxidant and antimicrobial activities. The major components of the oil were citronellol, geraniol, and isomenthone. In the combinations of G.O and antibiotics, the synergism of the Streptococcus pneumoniae to antibiotics advanced. When the time-kill data were evaluated, G.O + antibiotic combinations quickly diminished the viable cell count of S. pneumoniae from the 6th h. In this study, the combined use of existing antibiotics used in infection treatments with G.O could improve antibiotic effectiveness and thus prevent bacteria from developing antibiotic resistance. Full article
(This article belongs to the Special Issue Application and Chemical Characterization of Plant Natural Products)
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Review

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22 pages, 1502 KiB  
Review
Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities
by Rakeeb Ahmad Mir, Anshika Tyagi, Sofi Javed Hussain, Mohammed A. Almalki, Mohammad Tarique Zeyad, Rupesh Deshmukh and Sajad Ali
Plants 2024, 13(11), 1467; https://doi.org/10.3390/plants13111467 - 25 May 2024
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Abstract
Plants are an important source of essential bioactive compounds that not only have a beneficial role in human health and nutrition but also act as drivers for shaping gut microbiome. However, the mechanism of their functional attributes is not fully understood despite their [...] Read more.
Plants are an important source of essential bioactive compounds that not only have a beneficial role in human health and nutrition but also act as drivers for shaping gut microbiome. However, the mechanism of their functional attributes is not fully understood despite their significance. One such important plant is Crocus sativus, also known as saffron, which possesses huge medicinal, nutritional, and industrial applications like food and cosmetics. The importance of this plant is grossly attributed to its incredible bioactive constituents such as crocins, crocetin, safranal, picrocrocin, and glycosides. These bioactive compounds possess a wide range of therapeutic activities against multiple human ailments. Since a huge number of studies have revealed negative unwanted side effects of modern-day drugs, the scientific communities at the global level are investigating a large number of medicinal plants to explore natural products as the best alternatives. Taken into consideration, the available research findings indicate that saffron has a huge scope to be further explored to establish alternative natural-product-based drugs for health benefits. In this review, we are providing an update on the role of bioactive compounds of saffron as therapeutic agents (human disorders and antimicrobial activity) and its nutritional values. We also highlighted the role of omics and metabolic engineering tools for increasing the content of key saffron bioactive molecules for its mass production. Finally, pre-clinical and clinical studies seem to be necessary to establish its therapeutic potential against human diseases. Full article
(This article belongs to the Special Issue Application and Chemical Characterization of Plant Natural Products)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Oil/water biphasic solvent system for the eco-extraction and cosmetic formulation of Bixa orellana L.
Authors: Emilie Destandau
Affiliation: Institut de Chimie Analytique et Organique, Université d'Orléans - Pôle de chimie, rue de Chartres - BP 6759, 45067 Orléans Cedex 2, France
Abstract: Annatto, obtained from the seeds of achiote (Bixa orellana L.), is a widely used orange pigment rich in bixin and other apocarotenoids. This work introduces the optimisation of a green extraction method of pigments and antioxidant compounds from achiote as well as its integration in a one-step green extraction-cosmetic formulation process. A biphasic solvent system of oil and water was used to recover simultaneously polar polyphenols, and less polar compounds, such as δ-tocotrienol and bixin. The optimisation of the ultrasound assisted extraction is presented, as well as a comparison of different vegetable oils used as solvents of extraction. The composition, physico-chemical properties and antioxidant activity of the oils were studied and their extraction performance was compared. Refined sunflower oil prove to be a better solvent than virgin olive, jojoba, coconut and grapeseed oils. Both aqueous and oil phases displayed an interesting antioxidant capacity. The oil phase contained 0.9% of bixin, as well as minor apocarotenoids and δ-tocotrienol. Twelve compounds, mainly phenolics, were identified by UHPLC-DAD-HRMS/MS in the aqueous phase. Twenty-one volatile compounds were identified in the volatile fraction by SPME-GC-MS. Lastly, a one-step green process is proposed to combine the extraction and the cosmetic formulation of the bioactive compounds.

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