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Journals
Viruses
Special Issues
Endemic and Emerging Swine Viruses 2024
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Endemic and Emerging Swine Viruses 2024

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 433

Special Issue Editor

Dr. Douglas Gladue

E-Mail Website
Guest Editor
Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA
Interests: ASFV; CSFV; PRRSV; PEDV; PDCoV; SwIV; FMDV; swine viruses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the “Endemic and Emerging Swine Viruses” series (see the 2020, 2021, 2022 and 2023 editions), we are editing a 2024 edition of this very popular topic for new submissions.

The main topic of this Special Issue is agriculturally important swine viruses that have an effect on swine production or overall swine health. This includes viruses that have recently caused outbreaks, for example, African swine fever virus (ASFV) in Europe and Asia and classical swine fever virus (CSFV) in Japan, which are causing devastating losses to the swine industry. Endemic swine viruses include porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), swine influenza virus (SwIV), foot-and-mouth disease virus (FMDV), Senecavirus A (SVA), swine influenza, porcine circovirus (PCV), porcine sapelovirus (PSV), porcine astrovirus (PAstV), and any other endemic or emerging porcine viruses.

Dr. Douglas Gladue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • African swine fever virus (ASFV)
  • classical swine fever virus (CSFV)
  • porcine reproductive and respiratory syndrome virus (PRRSV)
  • porcine epidemic diarrhea virus (PEDV)
  • porcine deltacoronavirus (PDCoV)
  • swine influenza virus (SwIV)
  • foot-and-mouth disease virus (FMDV)

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Published Papers (1 paper)

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Research

19 pages, 10049 KiB  
Article
Transcriptome Analysis in Air–Liquid Interface Porcine Respiratory Epithelial Cell Cultures Reveals That the Betacoronavirus Porcine Encephalomyelitis Hemagglutinating Virus Induces a Robust Interferon Response to Infection
by Kaitlyn M. Sarlo Davila, Rahul K. Nelli, Juan C. Mora-Díaz, Yongming Sang, Laura C. Miller and Luis G. Giménez-Lirola
Viruses 2024, 16(6), 939; https://doi.org/10.3390/v16060939 (registering DOI) - 11 Jun 2024
Viewed by 136
Abstract
Porcine hemagglutinating encephalomyelitis virus (PHEV) replicates in the upper respiratory tract and tonsils of pigs. Using an air–liquid interface porcine respiratory epithelial cells (ALI-PRECs) culture system, we demonstrated that PHEV disrupts respiratory epithelia homeostasis by impairing ciliary function and inducing antiviral, pro-inflammatory cytokine, [...] Read more.
Porcine hemagglutinating encephalomyelitis virus (PHEV) replicates in the upper respiratory tract and tonsils of pigs. Using an air–liquid interface porcine respiratory epithelial cells (ALI-PRECs) culture system, we demonstrated that PHEV disrupts respiratory epithelia homeostasis by impairing ciliary function and inducing antiviral, pro-inflammatory cytokine, and chemokine responses. This study explores the mechanisms driving early innate immune responses during PHEV infection through host transcriptome analysis. Total RNA was collected from ALI-PRECs at 24, 36, and 48 h post inoculation (hpi). RNA-seq analysis was performed using an Illumina Hiseq 600 to generate 100 bp paired-end reads. Differential gene expression was analyzed using DeSeq2. PHEV replicated actively in ALI-PRECs, causing cytopathic changes and progressive mucociliary disruption. Transcriptome analysis revealed downregulation of cilia-associated genes such as CILK1, DNAH11, LRRC-23, -49, and -51, and acidic sialomucin CD164L2. PHEV also activated antiviral signaling pathways, significantly increasing the expression of interferon-stimulated genes (RSAD2, MX1, IFIT, and ISG15) and chemokine genes (CCL5 and CXCL10), highlighting inflammatory regulation. This study contributes to elucidating the molecular mechanisms of the innate immune response to PHEV infection of the airway epithelium, emphasizing the critical roles of the mucociliary, interferon, and chemokine responses. Full article
(This article belongs to the Special Issue Endemic and Emerging Swine Viruses 2024)
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