Applications of Extracellular Vesicles in Regenerative Medicine

Dear Colleagues,

Extracellular vesicles (EVs) have emerged as versatile entities in regenerative medicine, encompassing exosomes released through the fusion of multivesicular bodies with the cell membrane and micro/nano-vesicles directly released from the cell membrane. These membrane-bound vesicles are essential to intercellular communication, facilitating processes such as immune signaling, angiogenesis, the stress response, senescence, proliferation, and cell differentiation. The broad spectrum of EV involvement in various cellular activities makes them an intriguing focus area for therapeutic and diagnostic applications. Researchers are exploring the therapeutic potential of EVs in regenerative medicine, where they not only contribute to tissue repair and organ damage restoration but are also able to modulate cellular processes, promote the regeneration of affected tissues, and serve as effective delivery vehicles for therapeutic cargo. Further, in the realm of cancer research, they have been continually exploited in both therapy and diagnostics, often in tandem with bio-imaging (theranostics). The ongoing research is unveiling new applications and improving the integration of EVs within clinical settings, bringing us closer to achieving their full potential in the field of regenerative medicine. In this Special Issue, we will provide a platform to present the cutting-edge developments in EV research. It will not only highlight the most recent advancements but also discuss the challenges and opportunities in this rapidly evolving field. This dedicated Special Issue promises to be an invaluable resource for researchers seeking insights into the latest breakthroughs in, and the broader landscape of, EV studies.

Dr. Rohit K. Srivastava
Dr. Shreyas Kuddannaya
Guest Editors

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• extracellular vesicles
• regenerative medicine
• drug delivery
• tissue repair
• exosomes
• cancer
• cell-to-cell communication