Aging and Oxidative Stress in Nervous System
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1179
Special Issue Editor
Interests: aging and oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Currently, aging is considered to be a phenomenon with multifactorial causes. Therefore, a vast proliferation of theories and classifications have been proposed to explain the aging process. The most accepted hypothesis of aging is that of oxidative stress, which states that reactive oxygen species (ROS), produced via cellular aerobic metabolism, causes progressive oxidative damage throughout the cell, inducing its degeneration and death. In aerobic cells, mitochondria are the main source of ROS, which act mainly on the closest macromolecules such as the lipids of the mitochondrial membrane, the proteins of their enzymatic systems and, especially, the mitochondrial DNA. The lipids of cell membranes are biomolecules that are highly susceptible to being attacked by free radicals.
The nervous system is highly susceptible to oxidative stress and aging due to its rich chemical composition of polyunsaturated fatty acids, its high metabolic rate and a deficient antioxidant system. This involves a progressive loss of motor, sensory and cognitive functions, which is considered to happen because of the degenerative changes that occur with age. On the other hand, many pathologies of the nervous system occur more frequently as age progresses. The changes that are induced by aging and the associated oxidative stress in neurons and glial cells, as well as in the neurotransmission and in the central, peripheral and enteric nervous system, are of great interest, since they allow us to understand a universal phenomenon that affects all living things. Therefore, all levels of analysis are important, from the molecular and cellular levels to the tissue level, as are possible strategies, such as antioxidant molecules, to counteract it.
Dr. Laura Lõpez-Pingarrõn
Guest Editor
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Keywords
- oxidative stress
- aging
- central nervous system
- antioxidant
- enteric nervous system
