Current Issues in Molecular Biology

Special Issue Information

Dear Colleagues,

This Special Issue provides a focused exploration of the biochemical hallmarks underlying metabolic dysregulation in neurological disorders. Researchers have delved deeper into the intricate molecular mechanisms that link metabolism to the pathology of neurological diseases such as Alzheimer's, Parkinson's and amyotrophic lateral sclerosis. From this perspective, research is uncovering key molecular events such as alteration of mitochondrial metabolism, oxidative stress, protein aggregation and neuroinflammation. By unraveling the molecular complexities of metabolic alterations, this Special Issue aims to provide insights into the pathogenesis of neurological disorders while striving to identify potential molecular targets for therapeutic intervention. The field is ripe for innovative molecular-based approaches to diagnosis and treatment. Through a rigorous examination of molecular pathways, this Special Issue will advance our understanding of the molecular foundations of neurological diseases, providing a basis to guide future translational research.

Prof. Dr. Rafael Franco
Guest Editor

Manuscript Submission Information

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Keywords

metabolic dysregulation
neurological disorders
Alzheimer's disease
Parkinson's disease
neuroinflammation

Published Papers (1 paper)

Research

13 pages, 6416 KiB

Open AccessArticle

Evaluation of the Therapeutical Effect of Matricaria Chamomilla Extract vs. Galantamine on Animal Model Memory and Behavior Using 18F-FDG PET/MRI

by Roxana Iacob, Matei Palimariciuc, Tudor Florea, Cosmin Vasilica Pricope, Cristina Mariana Uritu, Bogdan Ionel Tamba, Teodor Marian Ionescu, Cati Raluca Stolniceanu, Wael Jalloul, Romeo Petru Dobrin, Lucian Hritcu, Oana Cioanca, Monica Hancianu, Alexandru Gratian Naum and Cipriana Stefanescu

Curr. Issues Mol. Biol. 2024, 46(5), 4506-4518; https://doi.org/10.3390/cimb46050273 - 9 May 2024

Viewed by 261

Abstract

The memory-enhancing activity of Matricaria chamomilla hydroalcoholic extract (MCE) is already being investigated by behavioral and biochemical assays in scopolamine-induced amnesia rat models, while the effects of scopolamine (Sco) on cerebral glucose metabolism are examined as well. Nevertheless, the study of the metabolic profile determined by an enriched MCE has not been performed before. The present experiments compared metabolic quantification in characteristic cerebral regions and behavioral characteristics for normal, only diseased, diseased, and MCE- vs. Galantamine (Gal)-treated Wistar rats. A memory deficit was induced by four weeks of daily intraperitoneal Sco injection. Starting on the eighth day, the treatment was intraperitoneally administered 30 min after Sco injection for a period of three weeks. The memory assessment comprised three maze tests. Glucose metabolism was quantified after the 18F-FDG PET examination. The right amygdala, piriform, and entorhinal cortex showed the highest differential radiopharmaceutical uptake of the 50 regions analyzed. Rats treated with MCE show metabolic similarity with normal rats, while the Gal-treated group shows features closer to the diseased group. Behavioral assessments evidenced a less anxious status and a better locomotor activity manifested by the MCE-treated group compared to the Gal-treated group. These findings prove evident metabolic ameliorative qualities of MCE over Gal classic treatment, suggesting that the extract could be a potent neuropharmacological agent against amnesia. Full article

(This article belongs to the Special Issue Metabolism and Molecular Pathology Related Features in Neurological Diseases)

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