Gastroenterology Insights

Special Issue Information

Dear Colleagues,

Liver diseases are a globally recognized cause of morbidity and mortality. The burden of these diseases has rapidly changed over the last decade due to the introduction in clinical practice of new antiviral agents for hepatitis C virus. Therefore, hepatologists are now tackling the burden of other pathological entities, such as metabolic-associated and hematological-associated liver diseases. A multidimensional diagnostic work-up is needed to ensure the optimal management of these patients. Furthermore, novel techniques and drugs are under investigation for the treatment of advanced stages of liver disease that are complicated by portal hypertension and hepatocellular carcinoma. Within this Special Issue, we will summarize the most updated and cutting-edge research in these fields. The first edition of the special issue can be found in https://www.mdpi.com/journal/gastroent/special_issues/novelties_hepatology.

Dr. Giovanni Marasco
Dr. Matteo Renzulli
Guest Editors

Manuscript Submission Information

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Related Special Issue

Published Papers (1 paper)

Research

14 pages, 1063 KiB

Open AccessArticle

Assessment of Cognitive Function in Romanian Patients with Chronic Alcohol Consumption

by Shandiz Morega, Claudiu-Marinel Ionele, Mihaela-Andreea Podeanu, Dan-Nicolae Florescu and Ion Rogoveanu

Gastroenterol. Insights 2024, 15(2), 433-446; https://doi.org/10.3390/gastroent15020031 - 17 May 2024

Viewed by 417

Abstract

Alcoholism presents a significant health concern with notable socioeconomic implications. Alcohol withdrawal syndrome (AWS) can manifest when individuals cease or drastically reduce their alcohol consumption after prolonged use. Non-alcoholic fatty liver disease (NAFLD) is characterized by substantial lipid accumulation in the liver cells of individuals with no history of alcohol consumption. There is evidence suggesting an association between cognitive impairment and both conditions. This study aimed to evaluate cognitive impairment in patients with NAFLD and AWS using the Mini-Mental State Examination (MMSE). This study involved 120 patients admitted to two hospitals in Craiova, Romania. Results indicated that patients with NAFLD did not exhibit cognitive impairment as measured by MMSE (Mean = 29.27, SD = 0.785). Conversely, patients with AWS showed more pronounced cognitive dysfunction, with a mean MMSE score at admission of 16.60 ± 4.097 and 24.60 ± 2.832 after 2 weeks under treatment with Vitamins B1 and B6 and Cerebrolysin. Additionally, our findings suggested that cognitive dysfunction among alcohol consumers was correlated with the severity of clinical symptoms, as demonstrated by the severity of tremors in our study. The two-week period under treatment and alcohol withdrawal was insufficient for cognitive function to return to normal levels. Observational studies on longer periods of time are advised. Full article

(This article belongs to the Special Issue Novelties in Diagnostics and Therapeutics in Hepatology: 2nd Edition)

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