Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 446
Special Issue Editor
Interests: colon cancer; gastric cancer; Notch signaling pathway; glutathione in cancer; antioxidant enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal cancers include a broad range of malignant tumors affecting organs such as the esophagus, stomach, colon, liver, and pancreas. These cancers pose a significant global health burden, resulting in high morbidity and mortality.
The pathophysiology of gastrointestinal cancers involves complex molecular and genetic alterations. Genetic mutations, such as those in tumor suppressor genes (e.g., TP53) and oncogenes (e.g., KRAS), play a crucial role in driving oncogenesis and tumor growth. Environmental risk factors, such as tobacco smoking, alcohol consumption, obesity, and certain dietary habits, also significantly contribute to the development of gastrointestinal cancers. Recognizing the complexities of gastrointestinal cancer pathophysiology is essential for developing effective therapeutic strategies. Emerging therapeutic approaches: targeted therapies, such as inhibitors of specific molecular pathways (e.g., tyrosine kinases); immunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy; nanomedicine and so on offer promising avenues to improve the outcomes of gastrointestinal cancers.
In conclusion, the pathophysiology of gastrointestinal cancers is multifaceted and involves complex molecular alterations. A comprehensive understanding of these processes paves the way for significant advances in therapeutic approaches.
This Special Issue “Gastrointestinal Cancer From Pathophysiology to Novel Therapeutic Approaches” of the International Journal of Molecular Sciences focuses on the study of molecular mechanisms and new therapeutic strategies for gastrointestinal cancers.
Dr. Marlena Brzozowa-Zasada
Guest Editor
Manuscript Submission Information
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Keywords
- gastrointestinal cancer
- molecular pathology
- innovative therapies
- targeted therapy
- immunotherapy
- cancer resistance
