Stem Cells in Human Development and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 November 2024 | Viewed by 1413
Special Issue Editor
Interests: pluripotent stem cells; early human development; organogenesis; CNS and PNS development; neural stem cells; neural crest; iPSC-derived disease models; neurodegeneration and regeneration; cancer stem cells; gene and cell therapy
Special Issue Information
Dear Colleagues,
Exciting advances in stem cell differentiation in 2D and 3D cell cultures that model tissues, organs or embryo stages have provided unprecedented insights into human development, but also novel tools to study human diseases and their cure. The latest high-throughput technologies of single cell or spatial transcriptomics, epigenomics and proteomics have allowed significant progress in interrogating cellular diversity, dynamics and pathological aspects.
Researchers in this field know that the experiments including differentiation and characterization of stem cell derivatives are complex, difficult and expensive, and solutions to the reported “wet” and “dry” problems must be found. We have progressed in producing better human cells and in interrogating the data from sequencing or imaging (either our own data or obtained from open sources).
Based on our of trust in these approaches for further progress in biology and medicine, I invite you to contribute to this Special Issue with research papers or review articles related to your interest in human development or disease, which include stem cell experiments or high-throughput stem cell characterization.
From tissue self-organization to developmental timing or morphogen gradients, your experiments involving stem cells and their progenies can unlock the fundamental biological concepts controlling development, diseases and ultimately regeneration. While several human pluripotent stem cell-based models, including genetic engineering tools, have been employed for several diseases, your studies including validation experiments that use disease-relevant human cells are still necessary for the not yet fully elucidated diseases or novel therapeutic strategies.
I look forward to your contribution!
Dr. Roxana Deleanu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pluripotency
- gastrulation
- neural induction
- neural crest
- organogenesis
- adult stem cells
- cancer stem cells
- stem cell-based disease models
