Mitral Valve Surgery: Current Status and Future Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 23 September 2024 | Viewed by 252

Special Issue Editors


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Guest Editor
Department of Cardiac Surgery and Heart Transplantation, Azienda Ospedaliera San Camillo Forlanini, 00151 Rome, Italy
Interests: cardiac surgery; aortic diseases; heart valve diseases; coronary artery bypass surgery; cardiothoracic surgery; cardiovascular; valvular heart disease

E-Mail Website
Guest Editor
Department of Cardiac Surgery and Heart Transplantation, Azienda Ospedaliera San Camillo Forlanini, 00151 Rome, Italy
Interests: cardiac surgery; heart valve diseases; coronary artery bypass surgery; cardiovascular

Special Issue Information

Dear Colleagues,

The treatment of mitral valve disease remains dynamic. The literature has previously shown the great advantage of mitral valve repair over replacement, especially in degenerative mitral valve disease. Since the introduction of the “French Correction” by Carpentier, which remarks the importance of leaflets’ resection, new concepts in leaflet repair techniques have emerged; these modifications have the final goal of the minimization of leaflet resection, focusing on techniques for leaflet remodeling and neochordae implantation.

Moreover, the surgical approach has changed over years and several different approaches have been proposed to minimize the invasiveness of the standard sternotomy approach, such as ministernotomy and minithoracotomy. The latest innovation, the endoscopic approach (including robotic surgery), has gained support in recent years.

To date, no particular technique has definitively demonstrated superiority relative to another, and the benefits of minimally invasive and robotic mitral valve surgery are still a point of debate.

In this scenario, recently, there has been a rapid adoption and implementation of transcatheter alternatives for mitral valve disease, including transcatheter edge-to-edge repair, transapical neochordal implantation and percutaneous annuloplasty (directly, or indirectly through coronary sinus remodeling). Finally, transcatheter alternatives for mitral valve replacement are emerging.

The aim of the present Research Topic is to give the latest evidence or new findings regarding the different approaches in cases of mitral valve repair (resectional vs non-resectional techniques, sternotomy vs minimally invasive/robotic surgery) or replacement (focusing on different surgical prostheses available); manuscripts within this area of research will be accepted.

Moreover, an analysis of transcatheter alternatives and comparison between the results of surgical or transcatheter techniques is encouraged for submission.

Dr. Antonio Lio
Dr. Marco Russo
Guest Editors

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Keywords

  • mitral valve
  • mitral valve repair
  • mitral valve replacement
  • minimally invasive surgery
  • robotic surgery

Published Papers (1 paper)

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Research

11 pages, 4921 KiB  
Article
First-in-Man Study of a Novel, Balloon-Adjustable Mitral Annuloplasty Ring
by Paul Werner, Tandis Aref, Keziban Uyanik-Uenal, Alfred Kocher, Piergiorgio Tozzi, Guenther Laufer and Martin Andreas
J. Clin. Med. 2024, 13(11), 3214; https://doi.org/10.3390/jcm13113214 - 30 May 2024
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Abstract
Objectives: Mitral valve repair is the current standard approach for mitral valve regurgitation. However, patients suffering from functional mitral regurgitation have a significant risk of recurrent regurgitation. Adjustable mitral rings may provide a solution for this adverse event. Methods: A single-center, [...] Read more.
Objectives: Mitral valve repair is the current standard approach for mitral valve regurgitation. However, patients suffering from functional mitral regurgitation have a significant risk of recurrent regurgitation. Adjustable mitral rings may provide a solution for this adverse event. Methods: A single-center, first-in-man clinical study was performed on patients suffering from mitral valve regurgitation. Patients were implanted with the study ring and followed for six months. A balloon catheter can be inserted into the study ring frame at any time after implantation and inflated independently in the areas P1, P2, or P3, which reduces the anterior-posterior diameter. Results: Five patients (75.4 ± 6.1 years; EuroSCORE II 2.1 ± 0.9%; three female) were successfully implanted. Mechanisms of mitral regurgitation were prolapse of the P2-segment in three patients and annular dilation in two patients. Surgical implantation according to the protocol was feasible and is described herein. Median cardiopulmonary bypass time and cross clamp time were 105 (118; 195) and 94 (90; 151) min, respectively. The median intensive care unit stay was 2 (2; 3) days. No perioperative, 30-day, or 6-month mortality was observed, and the repair was stable without residual or recurrent regurgitation ≥ grade 2. All patients reached the primary endpoint without device-related morbidity. Conclusions: Successful implantation was completed in five patients without device-related adverse events. Ring implantation was safe and feasible for all patients. The opportunity of post-implant adjustment to improve leaflet coaptation is a promising new therapeutic strategy that is assessed in a phase II study. Full article
(This article belongs to the Special Issue Mitral Valve Surgery: Current Status and Future Challenges)
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