Hand–Foot–Mouth Disease

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 769

Special Issue Editor

Special Issue Information

Dear Colleagues,

Hand–foot–mouth disease (HFMD) is a common infectious disease caused by a variety of enteroviruses.   Enterovirus 71 (EV71) and Coxsackie virus A 16 (CA-16) are the major etiologic agents of HFMD and herpangina. Children under five years are particularly susceptible to contracting HFMD. EV71 was first isolated from a child with encephalitis in California in 1969. Since that time, several epidemics of EV71 have been reported. The clinical spectrum of HFMD presents with a wide range of clinical manifestations, including cutaneous, visceral, and neurological disorders. In recent years, HFMD has been known to cause several large-scale outbreaks of severe complications in children involving the central nervous system (CNS). Although present in most countries, most outbreaks of the disease have been found in the Asia-Pacific region; the reasons for this phenomenon are unclear. Because of the potential for causing severe neurologic disease by this virus, we need to understand the epidemiology, pathogenesis, transmission mechanism, diagnosis, treatment, and prevention of HFMD. 

Prof. Dr. Kow-Tong Chen
Guest Editor

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Keywords

  • hand–foot–mouth disease
  • Coxsackie virus
  • epidemiology
  • pathogenesis
  • prevention

Published Papers (1 paper)

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Research

20 pages, 5838 KiB  
Article
Leucoverdazyls as Novel Potent Inhibitors of Enterovirus Replication
by Alexandrina S. Volobueva, Tatyana G. Fedorchenko, Galina N. Lipunova, Marina S. Valova, Valeriya A. Sbarzaglia, Anna S. Gladkikh, Olga I. Kanaeva, Natalia A. Tolstykh, Andrey N. Gorshkov and Vladimir V. Zarubaev
Pathogens 2024, 13(5), 410; https://doi.org/10.3390/pathogens13050410 - 15 May 2024
Viewed by 396
Abstract
Enteroviruses (EV) are important pathogens causing human disease with various clinical manifestations. To date, treatment of enteroviral infections is mainly supportive since no vaccination or antiviral drugs are approved for their prevention or treatment. Here, we describe the antiviral properties and mechanisms of [...] Read more.
Enteroviruses (EV) are important pathogens causing human disease with various clinical manifestations. To date, treatment of enteroviral infections is mainly supportive since no vaccination or antiviral drugs are approved for their prevention or treatment. Here, we describe the antiviral properties and mechanisms of action of leucoverdazyls—novel heterocyclic compounds with antioxidant potential. The lead compound, 1a, demonstrated low cytotoxicity along with high antioxidant and virus-inhibiting activity. A viral strain resistant to 1a was selected, and the development of resistance was shown to be accompanied by mutation of virus-specific non-structural protein 2C. This resistant virus had lower fitness when grown in cell culture. Taken together, our results demonstrate high antiviral potential of leucoverdazyls as novel inhibitors of enterovirus replication and support previous evidence of an important role of 2C proteins in EV replication. Full article
(This article belongs to the Special Issue Hand–Foot–Mouth Disease)
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