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Nano-Based Drug Delivery System: Recent Developments and Future Prospects

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A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2148

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Special Issue Editors

Prof. Dr. Lucas Amaral-Machado

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Guest Editor

Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; emulsified nanostructured systems; nanoparticles; drug formulation

Prof. Dr. Leonardo Miziara Barboza Ferreira

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Guest Editor

Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; bioadhesive nanostructure systems; nano-biointerface; quality control

Prof. Dr. Eryvaldo Sócrates Tabosa Do Egito

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Guest Editor

Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil
Interests: microemulsions; nanotechnology; drug delivery
Special Issues, Collections and Topics in MDPI journals

Dr. Jonatas Lobato Duarte

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Guest Editor

Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; drug delivery; nanocarriers development

Special Issue Information

Dear Colleagues,

Nanotechnology applied to therapeutics has been widely updated, promoting adequate alternatives to improve the therapeutic arsenal in numerous disorders and diseases. Many drugs have been targeted by universities, industries and research centres in order to improve their biopharmaceutical, pharmacokinetic, physicochemical and chemical characteristics. In addition, the toxicity and side effects, as well as the low specificity of the target sites, have challenged researchers around the world to invest in nanotechnology, providing updates, including unique and numerous nanotechnology-based drug delivery systems in the world scenario. This Special Issue is dedicated to the publication of original articles and reviews focused on the development of nanostructured systems for drug delivery (synthetic, natural and mineral source); preformulation studies, evaluation of in vitro and in vivo biological activity, toxicity, genotoxicity, stability, degradation and others.

Prof. Dr. Lucas Amaral-Machado
Prof. Dr. Leonardo Miziara Barboza Ferreira
Prof. Dr. Eryvaldo Sócrates Tabosa Do Egito
Dr. Jonatas Lobato Duarte
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanostructured carriers
microemulsions
nanoemulsions
nanoparticles
liposomes
nanogels
dendrimers

Published Papers (3 papers)

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Research

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17 pages, 2196 KiB

Open AccessArticle

Biological Response Following the Systemic Injection of PEG–PAMAM–Rhodamine Conjugates in Zebrafish

by Beatriz Custódio, Patrícia Carneiro, Joana Marques, Victoria Leiro, Ana M. Valentim, Mafalda Sousa, Sofia D. Santos, José Bessa and Ana P. Pêgo

Pharmaceutics 2024, 16(5), 608; https://doi.org/10.3390/pharmaceutics16050608 - 30 Apr 2024

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Abstract

Numerous therapeutic and diagnostic approaches used within a clinical setting depend on the administration of compounds via systemic delivery. Biomaterials at the nanometer scale, as dendrimers, act as delivery systems by improving cargo bioavailability, circulation time, and the targeting of specific tissues. Although evaluating the efficacy of pharmacological agents based on nanobiomaterials is crucial, conducting toxicological assessments of biomaterials is essential for advancing clinical translation. Here, a zebrafish larvae model was explored to assess the biocompatibility of poly(amido amine) (PAMAM), one of the most exploited dendrimers for drug delivery. We report the impact of a systemic injection of polyethylene glycol (PEG)-modified G4 PAMAM conjugated with rhodamine (Rho) as a mimetic drug (PEG–PAMAM–Rho) on survival, animal development, inflammation, and neurotoxicity. A concentration- and time-dependent effect was observed on mortality, developmental morphology, and innate immune system activation (macrophages). Significant effects in toxicological indicators were reported in the highest tested concentration (50 mg/mL PEG–PAMAM–Rho) as early as 48 h post-injection. Additionally, a lower concentration of PEG–PAMAM–Rho (5 mg/mL) was found to be safe and subsequently tested for neurotoxicity through behavioral assays. In accordance, no significative signs of toxicity were detected. In conclusion, the dose response of the animal was assessed, and the safe dosage for future use in theragnostics was defined. Additionally, new methodologies were established that can be adapted to further studies in toxicology using other nanosystems for systemic delivery. Full article

(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)

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Review

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14 pages, 1225 KiB

Open AccessReview

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

by Júlio Abreu Miranda, Yasmin Ferreira da Cruz, Ícaro Chaves Girão, Fabia Julliana Jorge de Souza, Wógenes Nunes de Oliveira, Éverton do Nascimento Alencar, Lucas Amaral-Machado and Eryvaldo Sócrates Tabosa do Egito

Pharmaceutics 2024, 16(5), 661; https://doi.org/10.3390/pharmaceutics16050661 - 15 May 2024

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Abstract

Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens. Moreover, their composition based on phospholipids, resembling that of the stratum corneum, facilitates adherence to the skin’s surface layers, thereby improving photoprotective efficacy. The research discussed in this review underscores the significant advantages of liposomes in photoprotection, including their ability to limit the systemic absorption of UV filters, enhance formulation stability, and augment photoprotective effects. However, despite these benefits, there remains a notable gap between the potential of liposomal systems and their utilization in sunscreen development. Consequently, this review emphasizes the importance of leveraging liposomes and related vesicular systems as innovative tools for crafting novel and more efficient photoprotective formulations. Full article

(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)

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33 pages, 8768 KiB

Open AccessReview

Recent Developments in CaCO₃ Nano-Drug Delivery Systems: Advancing Biomedicine in Tumor Diagnosis and Treatment

by Chenteng Lin, Muhammad Akhtar, Yingjie Li, Min Ji and Rongqin Huang

Pharmaceutics 2024, 16(2), 275; https://doi.org/10.3390/pharmaceutics16020275 - 15 Feb 2024

Viewed by 1140

Abstract

Calcium carbonate (CaCO₃), a natural common inorganic material with good biocompatibility, low toxicity, pH sensitivity, and low cost, has a widespread use in the pharmaceutical and chemical industries. In recent years, an increasing number of CaCO₃-based nano-drug delivery systems have been developed. CaCO₃ as a drug carrier and the utilization of CaCO₃ as an efficient Ca²⁺ and CO₂ donor have played a critical role in tumor diagnosis and treatment and have been explored in increasing depth and breadth. Starting from the CaCO₃-based nano-drug delivery system, this paper systematically reviews the preparation of CaCO₃ nanoparticles and the mechanisms of CaCO₃-based therapeutic effects in the internal and external tumor environments and summarizes the latest advances in the application of CaCO₃-based nano-drug delivery systems in tumor therapy. In view of the good biocompatibility and in vivo therapeutic mechanisms, they are expected to become an advancing biomedicine in the field of tumor diagnosis and treatment. Full article

(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)

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