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Sensors 2007, 7(11), 2671-2680; doi:10.3390/s7112671

Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
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Received: 31 October 2007 / Accepted: 9 November 2007 / Published: 12 November 2007
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Abstract

In this work, we reported a systematic investigation on the interactions betweenmethylene blue (MB) and surface-confined DNA by using electrochemical methods. Wedemonstrated that the redox potential of MB and binding and dissociation kinetics of MB toDNA differed significantly for single-stranded DNA (ss-DNA) and double-stranded DNA(ds-DNA) immobilized on gold electrodes. This was possibly due to the different bindingmechanism between MB and ss- or ds-DNA. This work might provide useful informationfor developing MB-based sequence-specific electrochemical DNA sensors.
Keywords: Electrochemical DNA sensors; methylene blue; electrochemical indicators. Electrochemical DNA sensors; methylene blue; electrochemical indicators.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pan, D.; Zuo, X.; Wan, Y.; Wang, L.; Zhang, J.; Song, S.; Fan, C. Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue. Sensors 2007, 7, 2671-2680.

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