Next Article in Journal
Feline Immunodeficiency Virus in South America
Next Article in Special Issue
Folding and Oligomerization of the gp2b/gp3/gp4 Spike Proteins of Equine Arteritis Virus in Vitro
Previous Article in Journal
Mining the Protein Data Bank to Differentiate Error from Structural Variation in Clustered Static Structures: An Examination of HIV Protease
Previous Article in Special Issue
Replication-Competent Recombinant Porcine Reproductive and Respiratory Syndrome (PRRS) Viruses Expressing Indicator Proteins and Antiviral Cytokines
Article Menu

Export Article

Open AccessArticle
Viruses 2012, 4(3), 363-382; doi:10.3390/v4030363

The Coronavirus E Protein: Assembly and Beyond

Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA
*
Author to whom correspondence should be addressed.
Received: 24 December 2011 / Revised: 18 February 2012 / Accepted: 27 February 2012 / Published: 8 March 2012
(This article belongs to the Special Issue Animal Arteriviruses and Coronaviruses)
View Full-Text   |   Download PDF [839 KB, uploaded 12 May 2015]   |  

Abstract

The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related. View Full-Text
Keywords: envelope protein; coronavirus assembly; ion channel; Golgi complex; membrane protein topology envelope protein; coronavirus assembly; ion channel; Golgi complex; membrane protein topology
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Ruch, T.R.; Machamer, C.E. The Coronavirus E Protein: Assembly and Beyond. Viruses 2012, 4, 363-382.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top