Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas
Abstract
:1. Introduction
2. Results
2.1. Toxicities
2.2. Survival
3. Discussion
4. Patients and Methods
4.1. Proton Beam Therapy Planning
4.2. Proton Beam Treatment
4.3. Follow-Up and Toxicity Evaluation
4.4. Statistical Methods
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Characteristics | n |
---|---|
Number of patients | 29 |
Gender, male/female | 22/7 |
Age (years); median (range) | 71 (38–87) |
PS 0/1/2 | 21/7/1 |
Tumor size; median (range) | 69 (50–139) |
50–100 mm/>100 mm | 22/7 |
CH HCV/HBV/alcoholic/others | 5/11/4/9 |
Child Pugh A/B | 24/5 |
Tumor thrombus PV/HV/bile duct | 9/4/1 |
Prior treatment TACE/RFA/surgery | 13/4/3 |
Operable/inoperable | 7/22 |
Solitary/multiple (two or more) | 14/15 |
Single nodular type/non single nodular type | 5/24 |
T stage 1/2/3a/3b/4 | 4/8/9/7/1 |
GTV (cm3); median (range) | 107 (23–1056) |
PTV (cm3); median (range) | 293 (138–1566) |
Liver volume (cm3); median (range) | 1310 (810–2259) |
Variables | HR | 95% CI | p-Value |
---|---|---|---|
T stage (T1-2/T3-4) | 0.28 | 0.09–0.87 | 0.03 |
Tumor size (≤100 mm/>100 mm) | 0.24 | 0.06–1.00 | 0.049 |
Volume of PTV (≤300 mL/>300 mL) | 1.04 | 0.27–4.02 | 0.95 |
Operable/inoperable | 0.63 | 0.14–2.74 | 0.54 |
History of previous treatment | 0.95 | 0.33–2.77 | 0.92 |
Author | Number | Median Tumor Size (Range) | Median Treatment Dose | OS 2 Years | LTC 2 Years |
---|---|---|---|---|---|
Mizumoto et al. [9] | 266 | 34 mm (6–130 mm) | 72.6 CGE/22 Fr | 61% (3 years) | 87% (3 years) |
Fukumitsu et al. [10] | 51 | 28 mm (8–93 mm) | 66.0 CGE/10 Fr | 49% (3 years) | 95% (3 years) |
Sugahara et al. [22] | 22 | 110 mm (100–140 mm) | 72.6 CGE/22 Fr | 36% | 87% |
Kimura et al. [23] | 24 | 90 mm (50–180 mm) | 72.6 CGE/22 Fr | 52% | 87% |
This study | 29 | 69 mm (50–139 mm) | 76.0 CGE/20 Fr | 61% | 95% |
Total Dose (CGE) | Number of Fractions | Cases (n = 29) | The Number of Re-Plan | Fraction at Re-Plan (Cases) |
---|---|---|---|---|
66 | 10 | 4 | - | - |
76 | 20 | 13 | 1 | 13 (1) |
80.5 | 23 | 1 | - | - |
80 | 25 | 1 | - | - |
67.5 | 25 | 1 | - | - |
70.4 | 32 | 5 | 5 | 20 (1), 22 (4) |
76 | 38 | 4 | 4 | 20 (2), 30 (2) |
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Share and Cite
Shibata, S.; Takamatsu, S.; Yamamoto, K.; Mizuhata, M.; Bou, S.; Sato, Y.; Kawamura, M.; Asahi, S.; Tameshige, Y.; Maeda, Y.; et al. Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas. Cancers 2018, 10, 71. https://doi.org/10.3390/cancers10030071
Shibata S, Takamatsu S, Yamamoto K, Mizuhata M, Bou S, Sato Y, Kawamura M, Asahi S, Tameshige Y, Maeda Y, et al. Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas. Cancers. 2018; 10(3):71. https://doi.org/10.3390/cancers10030071
Chicago/Turabian StyleShibata, Satoshi, Shigeyuki Takamatsu, Kazutaka Yamamoto, Miu Mizuhata, Sayuri Bou, Yoshitaka Sato, Mariko Kawamura, Satoko Asahi, Yuji Tameshige, Yoshikazu Maeda, and et al. 2018. "Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas" Cancers 10, no. 3: 71. https://doi.org/10.3390/cancers10030071