Table of Contents
Cancers, Volume 9, Issue 5 (May 2017)
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Cover Story (view full-size image) Lung cancer accounts for the most cancer-related deaths globally, indicating an urgent need to find [...] Read more. Lung cancer accounts for the most cancer-related deaths globally, indicating an urgent need to find strategies for its prevention and treatment. The Akt, mammalian target of rapamycin (mTOR) and p70 S6K, and the Ras-extracellular signal-regulated kinase (Erk1/2) pathways are activated in cancer leading to cell survival and growth. Exercise is associated with health benefits and in the present study we found that exposure of lung cancer cells to post exercise serum resulted in inhibition of cell proliferation and survival, as well as a significant reduction in activated Akt, mTOR, p70 S6K and Erk1/2. Our data suggest that post exercise serum has anti-cancer properties in lung cancer and deserves further systematic investigation. View this paper