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Appl. Sci. 2013, 3(2), 457-468; https://doi.org/10.3390/app3020457

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

1
Research Group of Heterocyclic Compounds, Chemistry Program, Faculty of Basic Sciences, The University of Atlantico, Km 7 Antigua vía Puerto Colombia, Barranquilla-Atlántico, Colombia
2
Research Group of Heterocyclic Compounds, Department of Chemistry, University of Valle, A. A 25360 Cali, Colombia
3
Department of Inorganic and Organic Chemistry, University of Jaén, 23071 Jaén, Spain
*
Author to whom correspondence should be addressed.
Received: 31 January 2013 / Revised: 26 February 2013 / Accepted: 27 March 2013 / Published: 16 April 2013
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
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Abstract

A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%). View Full-Text
Keywords: pyrazolines; cyclocondensation; sonication; chalcones; hydrazines pyrazolines; cyclocondensation; sonication; chalcones; hydrazines
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Trilleras, J.; Polo, E.; Quiroga, J.; Cobo, J.; Nogueras, M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Appl. Sci. 2013, 3, 457-468.

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