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Biology 2014, 3(2), 243-254; doi:10.3390/biology3020243

RNA Splicing Factors and RNA-Directed DNA Methylation

State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
Authors to whom correspondence should be addressed.
Received: 17 February 2014 / Revised: 18 March 2014 / Accepted: 20 March 2014 / Published: 26 March 2014
(This article belongs to the Special Issue DNA Methylation)
View Full-Text   |   Download PDF [219 KB, 28 March 2014; original version 26 March 2014]   |  


RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals. The heterochromation formation in yeast is mediated by RNAi-directed silencing mechanism, while the establishment of DNA methylation in plants is through the RNA-directed DNA methylation (RdDM) pathway. Recently, splicing factors are reported to be involved in both RNAi-directed heterochromatin formation in yeast and the RdDM pathway in plants. In yeast, splicing factors may provide a platform for facilitating the siRNA generation through an interaction with RDRC and thereby affect the heterochromatin formation, whereas in plants, various splicing factors seem to act at different steps in the RdDM pathway.
Keywords: splicing; DNA methylation; heterochromatin formation; siRNA; epigenetic regulation splicing; DNA methylation; heterochromatin formation; siRNA; epigenetic regulation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Huang, C.-F.; Zhu, J.-K. RNA Splicing Factors and RNA-Directed DNA Methylation. Biology 2014, 3, 243-254.

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