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Volume 84
Issue 2
10.3797/scipharm.1507-08
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and Characterization of Compounds Related to Lisinopril

by
Ambati V. RAGHAVA REDDY
1,2,*,
Srinivas GARAGA
1,
Chandiran TAKSHINAMOORTHY
1,
Andra NAIDU
2 and
Ramesh DANDALA
3
1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
3
Affliated supervisor, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(2), 269-278; https://doi.org/10.3797/scipharm.1507-08
Submission received: 9 July 2015 / Accepted: 18 October 2015 / Published: 18 October 2015
Versions Notes

Abstract

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
Keywords: Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities

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MDPI and ACS Style

RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A.; DANDALA, R. Synthesis and Characterization of Compounds Related to Lisinopril. Sci. Pharm. 2016, 84, 269-278. https://doi.org/10.3797/scipharm.1507-08

AMA Style

RAGHAVA REDDY AV, GARAGA S, TAKSHINAMOORTHY C, NAIDU A, DANDALA R. Synthesis and Characterization of Compounds Related to Lisinopril. Scientia Pharmaceutica. 2016; 84(2):269-278. https://doi.org/10.3797/scipharm.1507-08

Chicago/Turabian Style

RAGHAVA REDDY, Ambati V., Srinivas GARAGA, Chandiran TAKSHINAMOORTHY, Andra NAIDU, and Ramesh DANDALA. 2016. "Synthesis and Characterization of Compounds Related to Lisinopril" Scientia Pharmaceutica 84, no. 2: 269-278. https://doi.org/10.3797/scipharm.1507-08

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