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Proceeding Paper

A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy †

by
Manuel A. Rentería-Gómez
1,
Tannya R. Ibarra-Rivera
2 and
Rocío Gámez-Montaño
1,*
1
Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, 36050 Guanajuato, Mexico
2
Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, Fco. I. Madero s/n, Col. Mitras Centro, Monterrey, 64460 Nuevo León, Mexico
*
Author to whom correspondence should be addressed.
†
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Chem. Proc. 2021, 3(1), 59; https://doi.org/10.3390/ecsoc-24-08421
Published: 14 November 2020
(This article belongs to the Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry)
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Abstract

A series of six novel amide-xanthate products containing several fluorine atoms were prepared in moderate to good yields (40–92%) via an isocyanide-based multicomponent reaction (IMCR) of 5-CR by Ugi-4CR followed by an SN2 sequence in a one-pot manner. The design of molecules with fluorine atoms is of interest in medicinal chemistry and a research line of our interest. The role of fluorine atoms in biological properties is well documented, improving bioavailability, lipophilicity, and metabolic resistance in bioactive molecules.
Keywords: multicomponent reaction; amide-xanthates; heterocycle peptidomimetics; fluorine atoms multicomponent reaction; amide-xanthates; heterocycle peptidomimetics; fluorine atoms

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MDPI and ACS Style

Rentería-Gómez, M.A.; Ibarra-Rivera, T.R.; Gámez-Montaño, R. A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy. Chem. Proc. 2021, 3, 59. https://doi.org/10.3390/ecsoc-24-08421

AMA Style

Rentería-Gómez MA, Ibarra-Rivera TR, Gámez-Montaño R. A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy. Chemistry Proceedings. 2021; 3(1):59. https://doi.org/10.3390/ecsoc-24-08421

Chicago/Turabian Style

Rentería-Gómez, Manuel A., Tannya R. Ibarra-Rivera, and Rocío Gámez-Montaño. 2021. "A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy" Chemistry Proceedings 3, no. 1: 59. https://doi.org/10.3390/ecsoc-24-08421

APA Style

Rentería-Gómez, M. A., Ibarra-Rivera, T. R., & Gámez-Montaño, R. (2021). A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy. Chemistry Proceedings, 3(1), 59. https://doi.org/10.3390/ecsoc-24-08421

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