The Role of Glial Cells in Neuroinflammation, Neurodegeneration, and Neuroimmunomodulation

Dear Colleagues,

Glial cells, including astrocytes, microglia and oligodendrocytes, play a crucial role during normal homeostasis as well as in multiple neuroinflammatory disorders. The current knowledge gap due to our lack of proper understanding of the precise events and specific molecular and cellular mechanisms underlying glial–neurovascular interactions in multiple neuroinflammatory disorders is a major hurdle in the development of novel precision-targeted cellular and molecular therapies. Besides, there is a lack of adequate knowledge regarding the role of aging and sex-based differences underlying glial cell function in various neuroinflammatory and neurodegenerative disorders. Therefore, the major focus of this Special Issue is to gain novel insights into the underlying role of glial cells in various neuroinflammatory and neurodegenerative disorders, especially Alzheimer’s disease, Parkinson’s disease, stroke, traumatic brain injury, spinal cord injury, amyotrophic lateral sclerosis, frontotemporal dementia, posttraumatic stress disorder, and Huntington’s disease. We invite leading neuroscience research groups to contribute original full-length manuscripts, short reports and review articles, placing a particular emphasis on the role of glial cells in neuroinflammation, neurodegeneration, neuroregeneration, neuroplasticity, and neuroimmunomodulation, as well as motor and cognitive dysfunction. This includes discussions of vascular contributions to cognitive impairment & dementia. Studies investigating the role of glial cells using cutting-edge technologies like single-cell transcriptomics, molecular imaging, novel drug discovery, CRISPR, transgenic and knockout mice, iPS cells, stem cells, direct in vivo reprogramming of glial cells into neuronal lineage, gene therapy, gut microbiome axis, mitochondrial dysfunction, exosomes, as well as noncoding RNAs are of particular interest. Additionally, we welcome articles focused on deciphering the role of aging and sex-based differences underlying glial cell responses in various neuroinflammatory and neurodegenerative disorders.

Dr. Sudhanshu P. Raikwar
Dr. Anupama Rani
Guest Editors

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