Chromatin Proteomics

Dear Colleagues,

Since the identification of histones, as the principal component of the chromatin, several other classes of proteins have been identified. High Mobility Group (HMG) proteins, soon identified after histones, were followed by chromatin modifiers, epigenetic readers, and others. The complexity in the chromatin proteomic composition is increased by the high number and type of post-translational modifications, that have been discovered in the last years, that affect the structure and the function of both the histone and non-histone component of the chromatin. Many of these post-translational modifications (PTMs) are still under investigation and their function is still unclear.

Future challenges of chromatin proteomics will be to identify new PTMs and chromatin factors associated with them and to develop new technologies to dissect the genome architecture and the higher-order chromosomal structures. Studies on the Long Non-coding RNAs (lncRNAs) component of chromatin will shed light on lncRNAs involvement in chromatin remodeling and their interaction with the chromatin protein component. Understanding the critical role of chromatin composition and its function in the regulation of gene expression, in time and space, during development is still an big challenge.

This Special Issue on “Chromatin proteomics” will focus on proteomics studies in the field of chromatin composition, structure, and function. Special interest will be dedicated to advanced methods based on the combination of chromatin fractionation combined to quantitative proteomic analysis. The potential applications in the diagnosis and prognosis of human diseases of epigenetic studies will be addressed.

Prof. Dr. Guidalberto Manfioletti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Histones
• HMG
• Chromatin modifiers
• Epigenetics
• Post-translational modifications (PTMs)
• lncRNAs
• Protein-DNA interactions
• Protein-protein interaction
• Protein-RNA interaction
• Quantitative proteomics
• Genome architecture
• Higher-order chromosomal structures
• 3D nuclear space
• Cancer
• Neurodegenerative disorders