Cellular Mechanisms of Rheumatoid Arthritis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 3646
Special Issue Editor
Interests: rheumatic and musculoskeletal diseases (RMDs); rheumatoid arthritis; psoriatic arthritis; systemic lupus erythematosus; systemic sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Rheumatoid arthritis (RA) is a complex autoimmune disease that mainly affects peripheral joints, causing the destruction of joint structure and, ultimately, joint deformity and disability. RA can also affect other organs, including skin, lung, heart, and vasculature, which contribute to the morbidity and mortality. Multiple cell types play a key role in RA, including immune cells (monocytes/macrophages, B cells, and T cells); fibroblast-like synoviocytes (FLS), which are the joint stromal cells; endothelial cells; and osteoclasts. Research performed during recent decades has improved knowledge of the cellular mechanisms involved in the pathogenesis of RA. However, there are some aspects that have not been fully elucidated, such as the interactions between different cell types, the effect of current therapies at molecular and cellular level, as well as the identification of novel targets that can modulate the functional role of these cell types.
This Special Issue will include basic and translational original articles and reviews focused on cellular mechanisms involved in the pathogenesis of RA and the effect of current and novel treatments on these mechanisms, which will allow a better understanding of the pathogenesis of RA.
Dr. Samuel García Pérez
Guest Editor
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Keywords
- rheumatoid arthritis, immune cells
- fibroblast-like synoviocytes
- endothelial cells
- osteoclasts
- molecular mechanisms
- cellular responses
