Design and Application of Novel Nucleic Acid Probe
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".
Deadline for manuscript submissions: 1 August 2024 | Viewed by 900
Special Issue Editors
Interests: nucleic acid probe; label-free probe; DNA nanostructure; aptasensor
Special Issue Information
Dear Colleagues,
Nucleic acid-based biosensors are becoming popular in food, environmental, and healthcare applications, as nucleic acids are relatively easy to design and have a variety of different interactions with their targets. The success of nucleic acid-based biosensor is highly dependent on the design of nucleic acid probes. This Special Issue welcomes papers that analyze novel nucleic acid probe design and application. The probes can have intra-molecular or inter-molecular interaction with sequence-specific Watson–Crick hydrogen bonding or Hoogsteen hydrogen bonding, or non-specific hydrophobic interaction. The probes can be labeled or label free. The probes can either reveal a detectable signal or trigger a downstream reaction or conformational switch. Therefore, probes that have or can interact with their targets to form structures, such as triple helix, G-quadruplex, i-motif, aptamer, or self-assembled nanostructure, are within the scope. We welcome the application of these novel probes in the detection of different targets, including other nucleic acid sequences, proteins, small molecules, extracellular vesicles, or even cells.
Dr. Chiuan-Chian Chiou
Prof. Dr. Kou-Chen Liu
Guest Editors
Manuscript Submission Information
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Keywords
- nucleic acid probe
- label-free probe
- triplex forming oligonucleotides (TFOs)
- G-quadruplex
- i-motif
- aptamer/aptasensor
- DNA nanostructure
- hoogsteen hydrogen bonding
- conformational switch
