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Cancers
Special Issues
Polyphenols and Cancer Metabolism
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Polyphenols and Cancer Metabolism

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1111

Special Issue Editors

Dr. Ulrich Pfeffer

E-Mail Website
Guest Editor
Laboratory of Gene Expression Regulation, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
Interests: cancer genomics; molecular mechanisms of tumorigenesis; chemoprevention; melanoma; uveal melanoma
Special Issues, Collections and Topics in MDPI journals
Dr. Zeinab El Rashed

E-Mail Website
Guest Editor
Laboratory of Gene Expression Regulation, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
Interests: plant derived drugs; polyphenols; cancer metabolism; ferroptosis

Special Issue Information

Dear Colleagues,

Polyphenols naturally occur in many plants, where they act as a defense mechanism against pathogens and the effects of ultraviolet light exposure. A large body of literature indicates a role for polyphenols in the prevention and control of human diseases, especially cancer and cardiovascular disease. The antioxidant and anti-inflammatory functions of polyphenols are well established; many of them interfere with the activation of Nuclear factor Kappa B (NFkB), the master control factor of inflammation. Yet polyphenols likely have additional roles in human (patho-)physiology that are not necessarily linked to anti-inflammatory functions. Several studies attribute metabolic functions to polyphenols, and they have been considered as calorie restriction mimetics.

In the present Special Issue, we would like to focus on the (anti-)metabolic activities of dietary polyphenols, which merit more attention. Metabolic derangement is a hallmark of cancer, and aerobic glycolysis provides pyruvate, the basic building block for the production of nucleic acids and proteins that is required by fast-dividing cells. Interference with the neoplastic metabolic program can contribute to cancer prevention and therapy, but the true potential of such approaches has not yet been completely revealed.

We are pleased to invite you to contribute original articles, reviews, and commentaries on the above with the aim of reflecting the state of the art in research on polyphenols and cancer metabolism. Dietary compounds and control of metabolism are much debated beyond the scientific community, and incorrect information and myths pervade public discussion. For this reason, the present Special Issue intends to make a stark statement by segregating urban legends from scientific evidence.

We look forward to receiving your contributions.

Dr. Ulrich Pfeffer
Dr. Zeinab El Rashed
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • cancer metabolism
  • chemoprevention
  • therapy
  • calorie restriction mimetics

Published Papers (1 paper)

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Research

18 pages, 8710 KiB  
Article
Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
by Silvia Ravera, Claudio Pasquale, Isabella Panfoli, Matteo Bozzo, Dimitrios Agas, Silvia Bruno, Michael R. Hamblin and Andrea Amaroli
Cancers 2024, 16(9), 1642; https://doi.org/10.3390/cancers16091642 - 24 Apr 2024
Viewed by 818
Abstract
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting F [...] Read more.
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squamous cell carcinoma (HNSCC), and primary human fibroblasts. The treatment involved a 1 h exposure of cells to 0.1, 1.0, and 10 μM curcumin, followed or not by irradiation or the addition of the same concentration of pre-irradiated curcumin. Both instances involved a diode laser with a wavelength of 450 nm (0.25 W, 15 J, 60 s, 1 cm2, continuous wave mode). The treatment with non-irradiated 1 and 10 µM curcumin caused ATP synthase inhibition and a consequent reduction in the oxygen consumption rate (OCR) and the ATP/AMP ratio, which was associated with a decrement in lipid peroxidation accumulation and a slight increase in glutathione reductase and catalase activity. By contrast, 60 s curcumin irradiation with 0.25 W—450 nm caused a further oxidative phosphorylation (OxPhos) metabolism impairment that induced an uncoupling between respiration and energy production, leading to increased oxidative damage, a cellular growth and viability reduction, and a cell cycle block in the G1 phase. These effects appeared to be more evident when the curcumin was irradiated after cell incubation. Since cells belonging to the HNSCC microenvironment support tumor development, curcumin’s effects have been analyzed on primary human fibroblasts, and a decrease in cell energy status has been observed with both irradiated and non-irradiated curcumin and an increase in oxidative lipid damage and a slowing of cell growth were observed when the curcumin was irradiated before or after cellular administration. Thus, although curcumin displays an anti-cancer role on OHSU-974 in its native form, photoactivation seems to enhance its effects, making it effective even at low dosages. Full article
(This article belongs to the Special Issue Polyphenols and Cancer Metabolism)
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