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Advanced Biomaterials for Bone and Tooth Regeneration
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Advanced Biomaterials for Bone and Tooth Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 4227

Special Issue Editor

Dr. Daniel Humberto Pozza

E-Mail Website
Guest Editor
1. Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
2. Institute for Research and Innovation in Health—I3S, University of Porto, 4200-135 Porto, Portugal
Interests: pain; biomarkers; quantitative sensory tests; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone and tooth regeneration are the goal of best clinical practice in dentistry. The possibilities of restoring these important hard tissues have increased very rapidly in the last few decades. In this context, to provide the best restorative treatment for patients, the dental professional must be updated in the range of treatments to consciously choose the most suitable for each patient, individualizing the treatment. Due to its biological properties, autologous bone is the gold standard for bone reconstruction.

However, since it is not always possible to obtain autologous bone, to avoid the related bone harvesting morbidity and possible related surgical complications, other alternatives are increasingly used and preferred by many dentists. Biomaterials have been greatly improved in recent decades and can be used with a high rate of success, making the regenerative procedure easier for the dentist and more comfortable for the patient. Tissue engineering is also improving very fast, allowing bone regeneration and also providing a better future alternative for tooth reconstruction.

Thus, evidence-based dentistry from clinical trials and systematic reviews summarizing the advantages and disadvantages, indications, limitations, and best techniques are constantly required to keep professionals up to date. For this Special Issue, we aim to provide the most up-to-date information on these regenerative procedures.

Prof. Dr. Daniel Humberto Pozza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible materials
  • stem cells
  • regenerative medicine
  • sinus floor augmentation
  • alveolar bone loss
  • tissue engineering
  • dental tissues
  • gene editing
  • growth factors
  • neovascularization

Published Papers (3 papers)

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Research

17 pages, 6227 KiB  
Article
A Porous Fluoride-Substituted Bovine-Derived Hydroxyapatite Scaffold Constructed for Applications in Bone Tissue Regeneration
by Jithendra Ratnayake, Maree Gould, Niranjan Ramesh, Michael Mucalo and George J. Dias
Materials 2024, 17(5), 1107; https://doi.org/10.3390/ma17051107 - 28 Feb 2024
Viewed by 691
Abstract
Hydroxyapatite is widely used in bone implantation because of its similar mineral composition to natural bone, allowing it to serve as a biocompatible osteoconductive support. A bovine-derived hydroxyapatite (BHA) scaffold was developed through an array of defatting and deproteinization procedures. The BHA scaffold [...] Read more.
Hydroxyapatite is widely used in bone implantation because of its similar mineral composition to natural bone, allowing it to serve as a biocompatible osteoconductive support. A bovine-derived hydroxyapatite (BHA) scaffold was developed through an array of defatting and deproteinization procedures. The BHA scaffold was substituted with fluoride ions using a modified sol-gel method to produce a bovine-derived fluorapatite (BFA) scaffold. Fourier-transform infrared spectroscopy and X-ray diffraction analysis showed that fluoride ions were successfully substituted into the BHA lattice. According to energy dispersive X-ray analysis, the main inorganic phases contained calcium and phosphorus with a fluoride ratio of ~1–2 wt%. Scanning electron microscopy presented a natural microporous architecture for the BFA scaffold with pore sizes ranging from ~200–600 μm. The BHA scaffold was chemically stable and showed sustained degradation in simulated-body fluid. Young’s modulus and yield strength were superior in the BFA scaffold to BHA. In vitro cell culture studies showed that the BFA was biocompatible, supporting the proliferative growth of Saos-2 osteoblast cells and exhibiting osteoinductive features. This unique technique of producing hydroxyapatite from bovine bone with the intent of producing high performance biomedically targeted materials could be used to improve bone repair. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Bone and Tooth Regeneration)
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13 pages, 1740 KiB  
Article
Dynamics of CSBD Healing after Implementation of Dentin and Xenogeneic Bone Biomaterial
by Olga Cvijanović Peloza, Ana Terezija Jerbić Radetić, Mirjana Baričić, Luka Bukovac and Sanja Zoričić Cvek
Materials 2023, 16(4), 1600; https://doi.org/10.3390/ma16041600 - 14 Feb 2023
Cited by 1 | Viewed by 1107
Abstract
Autologous dentin is frequently used in guided bone regeneration due to its osteoinductive properties, which come from its similarity to native bone. On the other hand, the xenogeneic bone biomaterial Cerabone® serves as a biocompatible, but hardly resorbed biomaterial. During bone healing, [...] Read more.
Autologous dentin is frequently used in guided bone regeneration due to its osteoinductive properties, which come from its similarity to native bone. On the other hand, the xenogeneic bone biomaterial Cerabone® serves as a biocompatible, but hardly resorbed biomaterial. During bone healing, an inflammatory, vascular, and osteogenic response occurs in which cytokines such as tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and osteopontin (OPN) are released locally and systemically. The aim was to follow up the dynamics (on days 3, 7, 15, 21, and 30) of critical-sized bone defect (CSBD) healing after the implantation of bovine devitalized dentin, rat dentin, and xenogeneic bone biomaterial. For this purpose, histological and histomorphometric methods were employed. Additionally, serum concentrations of TNF-α, VEGF, and OPN were monitored in parallel to better understand the biomaterial-dependent systemic response in rats. At the last time interval, the results showed that the bone defect was bridged over in all three groups of biomaterials. The rat dentin group had the highest percentage of bone volume (BV/TV) and the least percentage of residual biomaterial (RB), which makes it the most optimal biomaterial for bone regeneration. Serum concentrations of the TNF-α, VEGF, and OPN refer to systemic response, which could be linked to intense bone remodeling between days 15 and 21 of the bone healing. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Bone and Tooth Regeneration)
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13 pages, 513 KiB  
Article
A Randomized Clinical Trial Comparing Implants Placed in Two Different Biomaterials Used for Maxillary Sinus Augmentation
by Francisco Correia, Sónia Alexandre Gouveia, Daniel Humberto Pozza, António Campos Felino and Ricardo Faria-Almeida
Materials 2023, 16(3), 1220; https://doi.org/10.3390/ma16031220 - 31 Jan 2023
Cited by 2 | Viewed by 1919
Abstract
The objective of this study was to compare marginal bone loss, surgical and clinical complications, and dental implant survival rate in bilateral maxillary sinus augmented by autologous or porcine xenograft. A randomized controlled clinical trial using split-mouth design enrolled 12 consent adult patients [...] Read more.
The objective of this study was to compare marginal bone loss, surgical and clinical complications, and dental implant survival rate in bilateral maxillary sinus augmented by autologous or porcine xenograft. A randomized controlled clinical trial using split-mouth design enrolled 12 consent adult patients (59.7 ± 8.7 years), who received bilateral maxillary sinus floor augmentation for oral rehabilitation with implant-supported prosthesis. Each patient received both the autologous bone from the mandible (control) or porcine xenograft (test) during the random bilateral sinus lift surgery. A total of 39 dental implants were placed in the posterior maxilla of the 12 patients after 6 months, being rehabilitated after the respective osseointegration period. Both graft materials demonstrated a high implant survival rate at 12 months: 95% for the xenograft side, only 1 implant without osseointegration, and 100% for the autologous side. Radiographic bone loss was low and similar for both groups: control group with a mean of 0.063 ± 0.126, and test group with a mean of 0.092 ± 0.163. No major surgical-related complications have occurred. Only one patient had several prosthetic complications due to fractures of prosthetic components. The maxillary sinus augmentation procedure, both with autologous bone and porcine xenograft materials, is an excellent clinical option procedure for the prosthetic rehabilitation of atrophic maxillae, with low marginal bone loss after one year follow-up, few clinical complications, and a high implant survival rate. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Bone and Tooth Regeneration)
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