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Microbiota and Microecological Health in Humans

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 709

Special Issue Editors


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Guest Editor
Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy
Interests: microbiota; microbiome; epigenetics; epigenetic biomarkers; DNA methylation modifications; mitochondrial DNA methylation; aging; nutrition; multi-drug resistance
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy
Interests: microbiota; microbiome; epigenetics; epigenetic biomarkers; DNA methylation modifications; mitochondrial DNA methylation; aging; nutrition; multi-drug resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human body is a complex microecology environment consisting of microorganisms that symbiotically dwell in different anatomic districts from the early neonatal state throughout the whole lifespan. Through the production of different metabolites, they perform many indispensable functions that define and contribute to human health. Being critically regulated by a host’s genetics, as well as stochastic and environmental factors, the composition and richness of microbiota are highly dynamic and the resulting changes significantly influence physiological and pathological processes in the host. In particular, the nutritional regime exerts short- and long-term effects on microbial communities via molecular mechanisms that are still elusive. This suggests that an extensive comprehension of human–microbiota ecosystems is necessary in order to promote and maintain health, as well as to prevent or attenuate the course of the disease.

This Special Issue will include contributions addressing insights on:

1) Microbial community networks across body niches;

2) The role of microbiota and its metabolites in the host’s biological processes;

3) The effect of environmental factors on host–microbiota interactions;

4) Microbial dysbiosis and human diseases;

5) Human microbiomes and antibiotic resistance;

6) The innovative therapeutic strategies for microbiota modulation in pathological conditions.

Prof. Dr. Dina Bellizzi
Dr. Patrizia D'Aquila
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • microbiome
  • host–microbiota interaction
  • dysbiosis
  • microbial metabolism
  • antibiotic resistance
  • probiotics
  • prebiotics
  • symbiotic

Published Papers (1 paper)

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Research

21 pages, 6094 KiB  
Article
Synergistic Inhibition of Synbiotic Cultures among Lactobacilli and Plant Extracts against Vaginal Discharge Causing Candida albicans
by Siriwoot Sookkhee, Phadungkiat Khamnoi, Thanapat Sastraruji, Sathian Boonkum, Nitwara Wikan and Wutigri Nimlamool
Nutrients 2024, 16(9), 1372; https://doi.org/10.3390/nu16091372 - 30 Apr 2024
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Abstract
Vulvovaginal candidiasis (VVC) is the most common cause of vaginal discharge among women. The present study aimed to investigate the synergistic anticandidal effect of lactobacillus cultures supplemented with plant extracts. Among 600 isolates of lactic acid bacteria, 41 isolates exhibited inhibitory activity against [...] Read more.
Vulvovaginal candidiasis (VVC) is the most common cause of vaginal discharge among women. The present study aimed to investigate the synergistic anticandidal effect of lactobacillus cultures supplemented with plant extracts. Among 600 isolates of lactic acid bacteria, 41 isolates exhibited inhibitory activity against Candida albicans ATCC10231. Six out of 41 cell-free supernatants demonstrated the most potent antibacterial and anticandidal activities. They also inhibited the clinical isolates of C. albicans, causing VVC and non-C. albicans. The synergistic effect between Lactobacillus crispatus 84/7 and Limosilactobacillus reuteri 89/4 was demonstrated by the lowest fractional inhibitory concentration index (FICI = 0.5). The synbiotic culture of bacterial combination, cultured with Jerusalem artichoke (H. tuberosus) extract, also exhibited the strongest inhibition against the tested C. albicans. Biofilm formation decreased after 12 h of incubation in the selected cell-free supernatants of this synbiotic culture. The anticandidal activity of crude extracts was lost after treatment with proteinase K and trypsin but not with heating conditions, suggesting that it may be a heat-stable substance. In conclusion, the combination of L. crispatus 84/7 and L. reuteri 89/4 with H. tuberosus may be a promising candidate for inhibiting Candida infection and biofilm formation, with the potential use as ingredients in vaginal biotherapeutic products. Full article
(This article belongs to the Special Issue Microbiota and Microecological Health in Humans)
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