Unlocking the Secrets behind Drug Resistance at the Cellular Level
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 September 2024 | Viewed by 705
Special Issue Editors
2. Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal
Interests: oncobiology; molecular pathology; ovarian cancer; drug resistance; drug repurposing
Interests: cancer resistance; pancreatic cancer; molecular biology; medical biotechnology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance is becoming a growing health concern. It can be developed by simple prokaryote cells to complex eukaryote cells, such as cancer cells. The World Health Organization (WHO) has identified antimicrobial resistance as one of the three significant public health challenges of the twenty-first century. Additionally, chemoresistance associated with cancer treatments is another big challenge of this century, and it is expected to increase in the coming years.
This Special Issue will contribute to the understanding of the underlying cellular mechanisms that lead to drug resistance. This issue aims to examine the mechanisms behind antibiotic resistance that are attributed to target protein alteration, integron operon network, anthropogenic activities, horizontal gene transfer, transposons and mutation in protein genes. In addition, it will investigate the ways by which drug resistance is developed in cancer, generally linked with several factors such as apoptotic pathways, immune system dysfunction, epigenetic changes and the activation of detox systems such as ROS. Other factors that can lead to chemoresistance include drug delivery problems, increased drug efflux or reduced influx, enhanced intrinsic DNA repair mechanisms and increased drug metabolism in the liver. Understanding the mechanisms behind drug resistance can trigger the development of new strategies to improve treatment efficacy in these two different disease contexts.
Dr. Sara Ricardo
Dr. Cristina Pinto Ribeiro Xavier
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- molecular mechanisms
- effective treatments
- drug tests
- bacterial resistance
- chemoresistance
