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Article

UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection

1
Leibniz Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena, Germany
2
Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University of Jena, Fraunhoferstr. 6, 07743 Jena, Germany
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(2), 478; https://doi.org/10.3390/s18020478
Submission received: 17 December 2017 / Revised: 18 January 2018 / Accepted: 30 January 2018 / Published: 6 February 2018

Abstract

Due to a worldwide increased use of pharmaceuticals and, in particular, antibiotics, a growing number of these substance residues now contaminate natural water resources and drinking supplies. This triggers a considerable demand for low-cost, high-sensitivity methods for monitoring water quality. Since many biological substances exhibit strong and characteristic absorption features at wavelengths shorter than 300 nm, UV spectroscopy presents a suitable approach for the quantitative identification of such water-contaminating species. However, current UV spectroscopic devices often show limited light-matter interaction lengths, demand sophisticated and bulky experimental infrastructure which is not compatible with microfluidics, and leave large fractions of the sample analyte unused. Here, we introduce the concept of UV spectroscopy in liquid-filled anti-resonant hollow core fibers, with large core diameters and lengths of approximately 1 m, as a means to overcome such limitations. This extended light-matter interaction length principally improves the concentration detection limit by two orders of magnitude while using almost the entire sample volume—that is three orders of magnitude smaller compared to cuvette based approaches. By integrating the fibers into an optofluidic chip environment and operating within the lowest experimentally feasible transmission band, concentrations of the application-relevant pharmaceutical substances, sulfamethoxazole (SMX) and sodium salicylate (SS), were detectable down to 0.1 µM (26 ppb) and 0.4 µM (64 ppb), respectively, with the potential to reach significantly lower detection limits for further device integration.
Keywords: optical fiber sensor; water monitoring; microstructured optical fibers; fiber-based optofluidics optical fiber sensor; water monitoring; microstructured optical fibers; fiber-based optofluidics

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MDPI and ACS Style

Nissen, M.; Doherty, B.; Hamperl, J.; Kobelke, J.; Weber, K.; Henkel, T.; Schmidt, M.A. UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection. Sensors 2018, 18, 478. https://doi.org/10.3390/s18020478

AMA Style

Nissen M, Doherty B, Hamperl J, Kobelke J, Weber K, Henkel T, Schmidt MA. UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection. Sensors. 2018; 18(2):478. https://doi.org/10.3390/s18020478

Chicago/Turabian Style

Nissen, Mona, Brenda Doherty, Jonas Hamperl, Jens Kobelke, Karina Weber, Thomas Henkel, and Markus A. Schmidt. 2018. "UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection" Sensors 18, no. 2: 478. https://doi.org/10.3390/s18020478

APA Style

Nissen, M., Doherty, B., Hamperl, J., Kobelke, J., Weber, K., Henkel, T., & Schmidt, M. A. (2018). UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection. Sensors, 18(2), 478. https://doi.org/10.3390/s18020478

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