Development of a CO2 Sensor for Extracorporeal Life Support Applications
Abstract
:1. Introduction
2. Materials and Methods
2.1. State-of-the-Art on CO2 Sensors
2.2. Design Requirements for CO2 Sensors Applied to ECLS Procedures
2.3. The Newly Developed CO2 Sensing Platform
- emission stage for the generation of the mid-IR beam;
- receiver stage for the detection, conditioning and amplification of the optical signal after CO2 absorption and;
- CPU for signal acquisition, processing, and communication with a host device.
2.4. Preliminary Analysis of Temperature Effect on Receiver Stage
2.5. Preliminary Analysis of Temperature Effect on the Emitter Stage
2.6. Experimental Analysis
2.7. Temperature Control Algorithm
- an initial phase performed at start-up, necessary to allow the sensor to reach the steady state temperature, and
- a phase in which the heating module is alternatively turned on and off by the CPU.
3. Results
3.1. Sensor Validation in Experimental Laboratory Setting
3.2. In Vivo Sensor Validation
4. Discussion and Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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CO2 Concentration Set-Point [v/v %] | Developed CO2 Sensor | “Gold Standard” Sensor |
---|---|---|
1.60% | 1.60% | 1.40% |
2.20% | 2.00% | 1.90% |
3.60% | 3.50% | 3.40% |
3.90% | 4.00% | 4.00% |
5.40% | 5.50% | 5.30% |
6.10% | 5.80% | 6.20% |
6.60% | 6.50% | 6.70% |
7.40% | 7.50% | 7.50% |
Average Error ± SD | 0.13 ± 0.09% | 0.15 ± 0.07% |
Gas Flow | Gas Flow | CO2 Concentration | CO2 Concentration | VCO2 | VCO2 |
---|---|---|---|---|---|
Developed Sensor | “Gold Standard” | Developed Sensor | “Gold Standard” | Developed Sensor | “Gold Standard” |
[L/min] | Sensor [L/min] | [v/v %] | Sensor [v/v %] | [mL/min] | Sensor [mL/min] |
1.60 | 1.50 | 3.80% | 3.80% | 60.8 | 57.0 |
1.00 | 1.00 | 7.00% | 6.90% | 70.0 | 69.0 |
1.00 | 1.00 | 7.10% | 7.00% | 71.0 | 70.0 |
1.10 | 1.00 | 8.20% | 8.30% | 90.2 | 83.0 |
1.50 | 1.40 | 7.60% | 7.60% | 114.0 | 106.4 |
2.20 | 2.10 | 5.20% | 5.00% | 114.4 | 105.0 |
3.60 | 3.60 | 3.60% | 3.40% | 129.6 | 122.4 |
0.80 | 0.70 | 5.00% | 4.80% | 40.0 | 33.6 |
3.10 | 3.00 | 4.40% | 4.40% | 136.4 | 132.0 |
4.50 | 4.50 | 3.60% | 3.40% | 162.0 | 153.0 |
Gas Flow Average Error ± SD [L/min] | CO2 Concentration Average Error ± SD [v/v%] | VCO2 Average Error ± SD [mL/min] | |||
0.06 ± 0.05 | 0.11 ± 0.09 | 5.7 ± 3 |
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Bellancini, M.; Cercenelli, L.; Severi, S.; Comai, G.; Marcelli, E. Development of a CO2 Sensor for Extracorporeal Life Support Applications. Sensors 2020, 20, 3613. https://doi.org/10.3390/s20133613
Bellancini M, Cercenelli L, Severi S, Comai G, Marcelli E. Development of a CO2 Sensor for Extracorporeal Life Support Applications. Sensors. 2020; 20(13):3613. https://doi.org/10.3390/s20133613
Chicago/Turabian StyleBellancini, Michele, Laura Cercenelli, Stefano Severi, Guido Comai, and Emanuela Marcelli. 2020. "Development of a CO2 Sensor for Extracorporeal Life Support Applications" Sensors 20, no. 13: 3613. https://doi.org/10.3390/s20133613