Development and Applications of Compton Camera—A Review

Round 1

Reviewer 1 Report

Thank you for reviewing Compton camera technology with many references.

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

The review is very interesting and well organized. I have the following minor comments:

1)     Figure 1 is taken from the book by Glenn Knoll (Radiation Detection and Measurements, Wiley). Please carefully check the copyright.

2)     Most of the citations are to papers by Japanese groups. I recommend to extend bibliography including European contributions on gamma ray spectrometer based on SiPM:

·        page 4: when discussing SPECT you can mention also multimodal imaging (i.e. combination of SPECT with MRI) and cite https://doi.org/10.1109/TRPMS.2019.2951355 as an example of SPECT based on SiPMs

·        section 3.4: when discussing environmental monitoring, you can cite these gamma cameras based on SiPM coupled to scintillators: 2” NaI ( https://doi.org/10.3390/s22041412 ) also flying on a drone and 3” LaBr3 ( https://doi.org/10.1109/JETCAS.2020.3029570 ) including embedded machine learning for direction sensitivity.

3)     Page 5, define DSSD

4)     Section 4: discuss the computational cost of the discussed methods and clarify if image reconstruction is performed off line or in real time (and on which hardware platform).

5)     Section 5: prove some quantitative summary comparison of Compton cameras vs collimator detectors. Discuss how the spatial resolution, especially in the medical field, could be improved.

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

This review paper tries to summarize the history and recent progress of Compton imaging.

Generally, the paper is well written, however, citation is a bit biased to the specific working groups and some references are lacked. You should cite more papers with wider aspect.

Here are detailed comments.

ll73 “that can efficiently these polarized γ-rays” a verb is lacked.

Table1 PBq

 

ll325 Regarding solid detector based electron tracking Compton camera, there are more works, such as

Wen, Jiaxing, et al. "Optimization of Timepix3-based conventional Compton camera using electron track algorithm." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment  1021 (2022): 165954.

Yoshihara, Y., et al. "Development of electron-tracking Compton imaging system with 30-μm SOI pixel sensor." Journal of Instrumentation  12.01 (2017): C01045.

 

ll 503 I think you are citing the wrong paper, it should be [149], NOT [148] for Compton-PET

Figure 9 seems to be also wrong. [149] shows the simultaneous visualization of 111In and 18F with PET and Compton imaging. Please replace the figure.

[148] is not Compton-PET, just a Compton camera.

 

ll679 for Fukushima related applications, there are earlier works to be referenced, such as,

Shikaze, Yoshiaki, et al. "Field test around Fukushima Daiichi nuclear power plant site using improved Ce: Gd3 (Al, Ga) 5O12 scintillator Compton camera mounted on an unmanned helicopter." Journal of Nuclear Science and Technology  53.12 (2016): 1907-1918.

Jiang, Jianyong, et al. "A prototype of aerial radiation monitoring system using an unmanned helicopter mounting a GAGG scintillator Compton camera." Journal of Nuclear Science and Technology  53.7 (2016): 1067-1075.

 

There will be other Compton imaging systems to be mentioned.

multi-pixel CdTe based Compton camera

Tomita, Hideki, et al. "Gamma-ray source identification by a vehicle-mounted 4π Compton imager." 2020 IEEE/SICE International Symposium on System Integration (SII) . IEEE, 2020.

Medipix single layer CdTe based CC

Turecek, D., et al. "Single layer Compton camera based on Timepix3 technology." Journal of Instrumentation  15.01 (2020): C01014.

GAGG Omnidirectional

Takahashi, Tone, et al. "Development of omnidirectional gamma-imager with stacked scintillators." 2013 3rd International Conference on Advancements in Nuclear Instrumentation, Measurement Methods and their Applications (ANIMMA) . IEEE, 2013.

some groups mention to use TES for Compton imager

Iyomoto, Naoko, et al. "Development of gamma-ray position-sensitive transition-edge sensor microcalorimeters." Journal of Low Temperature Physics  200.5 (2020): 233-238.

Author Response

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Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

All the previous comments were well addressed and the manuscript seems to be ready for publication.