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Sensors
Volume 22
Issue 6
10.3390/s22062141
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Article

Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring

by
Miguel Vidal
1,
Maria Simone Soares
1,
Médéric Loyez
2,
Florinda M. Costa
1,
Christophe Caucheteur
2,
Carlos Marques
1,
Sónia O. Pereira
1 and
Cátia Leitão
1,*
1
Physics Department & I3N, University of Aveiro, 3810-193 Aveiro, Portugal
2
Electromagnetism and Telecommunication Department, University of Mons, 31 Bld Dolez, 7000 Mons, Belgium
*
Author to whom correspondence should be addressed.
Sensors 2022, 22(6), 2141; https://doi.org/10.3390/s22062141
Submission received: 8 February 2022 / Revised: 23 February 2022 / Accepted: 8 March 2022 / Published: 10 March 2022
(This article belongs to the Special Issue Plasmonic Optical Fiber Sensors: Technology and Applications)
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Abstract

Optical fiber technology has rapidly progressed over the years, providing valuable benefits for biosensing purposes such as sensor miniaturization and the possibility for remote and real-time monitoring. In particular, tilted fiber Bragg gratings (TFBGs) are extremely sensitive to refractive index variations taking place on their surface. The present work comprises a case-study on the impact of different methods of analysis applied to decode spectral variations of bare and plasmonic TFBGs during the detection of N-terminal B-type natriuretic peptide (NT-proBNP), a heart failure biomarker, namely by following the most sensitive mode, peaks of the spectral envelopes, and the envelopes’ crossing point and area. Tracking the lower envelope resulted in the lowest limits of detection (LOD) for bare and plasmonic TFBGs, namely, 0.75 ng/mL and 0.19 ng/mL, respectively. This work demonstrates the importance of the analysis method on the outcome results, which is crucial to attain the most reliable and sensitive method with lower LOD sensors. Furthermore, it makes the scientific community aware to take careful attention when comparing the performance of different biosensors in which different analysis methods were used.
Keywords: optical fiber sensors; surface plasmon resonance (SPR); spectral demodulation methods; cardiac biomarker; NT-proBNP; biosensors optical fiber sensors; surface plasmon resonance (SPR); spectral demodulation methods; cardiac biomarker; NT-proBNP; biosensors

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MDPI and ACS Style

Vidal, M.; Soares, M.S.; Loyez, M.; Costa, F.M.; Caucheteur, C.; Marques, C.; Pereira, S.O.; Leitão, C. Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring. Sensors 2022, 22, 2141. https://doi.org/10.3390/s22062141

AMA Style

Vidal M, Soares MS, Loyez M, Costa FM, Caucheteur C, Marques C, Pereira SO, Leitão C. Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring. Sensors. 2022; 22(6):2141. https://doi.org/10.3390/s22062141

Chicago/Turabian Style

Vidal, Miguel, Maria Simone Soares, Médéric Loyez, Florinda M. Costa, Christophe Caucheteur, Carlos Marques, Sónia O. Pereira, and Cátia Leitão. 2022. "Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring" Sensors 22, no. 6: 2141. https://doi.org/10.3390/s22062141

APA Style

Vidal, M., Soares, M. S., Loyez, M., Costa, F. M., Caucheteur, C., Marques, C., Pereira, S. O., & Leitão, C. (2022). Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring. Sensors, 22(6), 2141. https://doi.org/10.3390/s22062141

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