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Article

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

by
Ivan Rui Lopes Albuquerque
1,2,
Sara Lima Cordeiro
1,
Dayanne Lopes Gomes
1,
Juliana Luporini Dreyfuss
3,
Luciana Guimarães Alves Filgueira
1,
Edda Lisboa Leite
1,
Helena Bonciani Nader
3 and
Hugo Alexandre Oliveira Rocha
1,2,*
1
Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal-RN 59078-970, Brazil
2
Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal-RN 59078-970, Brazil
3
Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo-SP 04044-020, Brazil
*
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(8), 2722-2740; https://doi.org/10.3390/md11082722
Submission received: 3 May 2013 / Revised: 4 June 2013 / Accepted: 17 June 2013 / Published: 2 August 2013
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Abstract

Fucan is a term that defines a family of homo- and hetero-polysaccharides containing sulfated l-fucose in its structure. In this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-α). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. In summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.
Keywords: fucan; brown seaweed; pain; analgesic; dictyotales fucan; brown seaweed; pain; analgesic; dictyotales

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MDPI and ACS Style

Albuquerque, I.R.L.; Cordeiro, S.L.; Gomes, D.L.; Dreyfuss, J.L.; Filgueira, L.G.A.; Leite, E.L.; Nader, H.B.; Rocha, H.A.O. Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis. Mar. Drugs 2013, 11, 2722-2740. https://doi.org/10.3390/md11082722

AMA Style

Albuquerque IRL, Cordeiro SL, Gomes DL, Dreyfuss JL, Filgueira LGA, Leite EL, Nader HB, Rocha HAO. Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis. Marine Drugs. 2013; 11(8):2722-2740. https://doi.org/10.3390/md11082722

Chicago/Turabian Style

Albuquerque, Ivan Rui Lopes, Sara Lima Cordeiro, Dayanne Lopes Gomes, Juliana Luporini Dreyfuss, Luciana Guimarães Alves Filgueira, Edda Lisboa Leite, Helena Bonciani Nader, and Hugo Alexandre Oliveira Rocha. 2013. "Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis" Marine Drugs 11, no. 8: 2722-2740. https://doi.org/10.3390/md11082722

APA Style

Albuquerque, I. R. L., Cordeiro, S. L., Gomes, D. L., Dreyfuss, J. L., Filgueira, L. G. A., Leite, E. L., Nader, H. B., & Rocha, H. A. O. (2013). Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis. Marine Drugs, 11(8), 2722-2740. https://doi.org/10.3390/md11082722

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