Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids

Da Costa, Elisabete; Silva, Joana; Mendonça, Sofia Hoffman; Abreu, Maria Helena; Domingues, Maria Rosário

doi:10.3390/md14050101

Open AccessReview

Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids

by

Elisabete Da Costa

¹

,

Joana Silva

²,

Sofia Hoffman Mendonça

²,

Maria Helena Abreu

³ and

Maria Rosário Domingues

^1,*

¹

Centro de Espectrometria de Massa, Departamento de Química & QOPNA, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal

²

Allmicroalgae—Natural Products S.A., Avenida das Forças Armadas, 125, 7º piso, 1600-079 Lisboa, Portugal

³

ALGAplus-Produção e Comercialização de Algas e Derivados, Lda., 3830-196 Ílhavo, Portugal

^*

Author to whom correspondence should be addressed.

Mar. Drugs 2016, 14(5), 101; https://doi.org/10.3390/md14050101

Submission received: 19 February 2016 / Revised: 9 May 2016 / Accepted: 12 May 2016 / Published: 19 May 2016

(This article belongs to the Special Issue Marine Fatty Acids-2016)

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Abstract

In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated fatty acids (PUFAs) like n-3 α-linolenic (ALA 18:3), eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6). GLs comprise three major classes: monogalactosyldiacyl glycerolipids (MGDGs), digalactosyl diacylglycerolipids (DGDGs) and sulfoquinovosyl diacylglycerolipids (SQDGs), whose composition in FA directly depends on the growth conditions. Some of these lipids are high value-added compounds with antitumoral, antimicrobial and anti-inflammatory activities and also with important nutritional significance. To fully explore GLs’ bioactive properties it is necessary to fully characterize their structure and to understand the relation between the structure and their biological properties, which can be addressed using modern mass spectrometry (MS)-based lipidomic approaches. This review will focus on the up-to-date FA composition of GLs identified by MS-based lipidomics and their potential as phytochemicals.

Keywords: lipidomic; glycolipids; microalgae; fatty acids; mass spectrometry; bioprospection

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MDPI and ACS Style

Da Costa, E.; Silva, J.; Mendonça, S.H.; Abreu, M.H.; Domingues, M.R. Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids. Mar. Drugs 2016, 14, 101. https://doi.org/10.3390/md14050101

AMA Style

Da Costa E, Silva J, Mendonça SH, Abreu MH, Domingues MR. Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids. Marine Drugs. 2016; 14(5):101. https://doi.org/10.3390/md14050101

Chicago/Turabian Style

Da Costa, Elisabete, Joana Silva, Sofia Hoffman Mendonça, Maria Helena Abreu, and Maria Rosário Domingues. 2016. "Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids" Marine Drugs 14, no. 5: 101. https://doi.org/10.3390/md14050101

APA Style

Da Costa, E., Silva, J., Mendonça, S. H., Abreu, M. H., & Domingues, M. R. (2016). Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids. Marine Drugs, 14(5), 101. https://doi.org/10.3390/md14050101

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids

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