Syntheses of Benzo[d]Thiazol-2(3H)-One Derivatives and Their Antidepressant and Anticonvulsant Effects

Round  1

Reviewer 1 Report

The matter of the research seems to be very interesting, but there are some errors in the reviewed paper. Before publishing, authors should make some corrections on their manuscript.

·         Why schemes 1 and 2 are in the experimental part? I think that they have to be moved to chapter 2.1. Synthesis.

·         All spectra should be in the supplementary part. All researchers should have access to them.

·         I did not find information on what purity of the compounds were obtained. The highest purity compounds should be given for biological tests.

·         The authors have to improve the scheme 1. The numbers of the compounds should be written in bold type.

Author Response

Dear editor

I revised my paper according to the reviewer’s comment. The modified part is underlined in the text.

I would like to thank you for your kind consideration to publish this paper. 

Thank you for your consideration.
Sincerely yours,

 Li-Ping Guan

Comment:

1． Why schemes 1 and 2 are in the experimental part? I think that they have to be moved to chapter 2.1. Synthesis.

Answer: we revised in the paper.

2． All spectra should be in the supplementary part. All researchers should have access to them.

Answer:  All spectra place them in the supplementary part.

3.   I did not find information on what purity of the compounds were obtained. The highest purity compounds should be given for biological tests.

Answer: all compounds were crystallized from MeOH. The melting point of some compounds can also prove the relative purity. In addition, NMR spectra also show that the compounds are relatively pure. Because the spectral capacity is too large to upload. For compounds with good activity, the purity will be determined by elemental analysis.

4.  The authors have to improve the scheme 1. The numbers of the compounds should be written in bold type.

Answer: we revised the numbers of the compounds in the text.

Reviewer 2 Report

Comments:

In this manuscript, the authors have reported the synthesis Benzo[d]thiazol-2(3H)-one derivatives followed by studied their antidepressant and anticonvulsant activities. The authors have inspired from the investigation of secondary metabolites of the antarcitic-derived fungus Penicillium sp.  Accordingly, in this study the authors have synthesized thirty-four benzo[d]thiazole derivatives and found that compounds 2c and 2d showed the highest antidepressant and anticonvulsant activities by FST comparing with the control fluoxetine. Also, in the MES test 3n and 3q showed the anticonvulsant effect. Apart from this, the authors have also investigated the mechanism of antidepressant activity of 2c and 2d via the disruption in release of neurotransmitters in CNS

Overall, the authors have written the manuscript well with relevant citations. Hence, it can be accepted in the current form.

Author Response

Dear editor

Thank you for your email.

I would like to thank you for your kind consideration to publish this paper. 

Thank you for your consideration.
Sincerely yours,

Li-Ping Guan