Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity

Zhang, Hairong; Zou, Jiabin; Yan, Xiaoxue; Chen, Junlong; Cao, Xiujiao; Wu, Jialing; Liu, Yinghui; Wang, Tingting

doi:10.3390/md19040180

Open AccessReview

Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity

by

Hairong Zhang

,

Jiabin Zou

,

Xiaoxue Yan

,

Junlong Chen

,

Xiujiao Cao

,

Jialing Wu

,

Yinghui Liu

and

Tingting Wang

^*

Li Dak Sum Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China

^*

Author to whom correspondence should be addressed.

Mar. Drugs 2021, 19(4), 180; https://doi.org/10.3390/md19040180

Submission received: 10 March 2021 / Revised: 19 March 2021 / Accepted: 21 March 2021 / Published: 25 March 2021

(This article belongs to the Special Issue Marine Fungal Metabolites: Structures, Activities and Biosynthesis)

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Abstract

Macrolides are a significant family of natural products with diverse structures and bioactivities. Considerable effort has been made in recent decades to isolate additional macrolides and characterize their chemical and bioactive properties. The majority of macrolides are obtained from marine organisms, including sponges, marine microorganisms and zooplankton, cnidarians, mollusks, red algae, bryozoans, and tunicates. Sponges, fungi and dinoflagellates are the main producers of macrolides. Marine macrolides possess a wide range of bioactive properties including cytotoxic, antibacterial, antifungal, antimitotic, antiviral, and other activities. Cytotoxicity is their most significant property, highlighting that marine macrolides still encompass many potential antitumor drug leads. This extensive review details the chemical and biological diversity of 505 macrolides derived from marine organisms which have been reported from 1990 to 2020.

Keywords: macrolides; marine organisms; chemical diversity; biological diversity; cytotoxicity

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MDPI and ACS Style

Zhang, H.; Zou, J.; Yan, X.; Chen, J.; Cao, X.; Wu, J.; Liu, Y.; Wang, T. Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity. Mar. Drugs 2021, 19, 180. https://doi.org/10.3390/md19040180

AMA Style

Zhang H, Zou J, Yan X, Chen J, Cao X, Wu J, Liu Y, Wang T. Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity. Marine Drugs. 2021; 19(4):180. https://doi.org/10.3390/md19040180

Chicago/Turabian Style

Zhang, Hairong, Jiabin Zou, Xiaoxue Yan, Junlong Chen, Xiujiao Cao, Jialing Wu, Yinghui Liu, and Tingting Wang. 2021. "Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity" Marine Drugs 19, no. 4: 180. https://doi.org/10.3390/md19040180

APA Style

Zhang, H., Zou, J., Yan, X., Chen, J., Cao, X., Wu, J., Liu, Y., & Wang, T. (2021). Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity. Marine Drugs, 19(4), 180. https://doi.org/10.3390/md19040180

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Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity

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